PMID: 8607940Dec 1, 1995Paper

Interleukin-1 beta (IL-1 beta) is increased in the follicular fluids of patients with premature luteinization

American Journal of Reproductive Immunology : AJRI
H F ChenY S Yang

Abstract

Most, but not all, studies indicate that premature luteinization correlates with poor pregnancy outcome in in-vitro fertilization (IVF) programs. It remains unclear whether cytokines (IL-1 beta, TNF alpha), the established immune mediators, play a role in regulation or initiation of an abnormal follicular or embryo development in patients with premature luteinization. Levels of cytokines (IL-1 beta, TNF alpha), estradiol (E2) progesterone (P4), and androstenedione (A'ione) were examined in 18 preovulatory follicular fluid (FF) samples from patients with premature luteinization (group 1) and 3 FF samples from patients without premature luteinization (group 2). The number of oocytes recovered, fertilization rate, and pregnancy outcome were evaluated in these two groups. IL-1 beta (25.4 +/ 11.9 pg/ml, mean +/ SD) and TNF alpha (13.4 +/ 10.7 pg/ml) were present in these FF samples. The mean level of IL-1 beta in group 1 was significantly higher than that in group 2 (37.3 +/ 12.3 vs. 20.0 +/ 7.6 pg/ml; P < 0.00001) and the mean level of E2 was significantly lower in group 1 than that in group 2 (1064 +/ 686 vs. 1570 +/ 641 ng/ml; P = 0.02). The levels of TNF alpha, P4, and A'ione showed no distinction between these two groups. There...Continue Reading

References

Dec 1, 1992·Fertility and Sterility·Z Ben-Rafael, R Orvieto
Aug 1, 1991·Fertility and Sterility·M ZoltiR N Apte
Nov 1, 1990·The Journal of Clinical Endocrinology and Metabolism·J A LoukidesM L Polan
Mar 1, 1988·Fertility and Sterility·R PunnonenP Tuohimaa

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