PMID: 9006348Jan 1, 1997Paper

Interleukin-1 beta-induced disruption of the retinal vascular barrier of the central nervous system is mediated through leukocyte recruitment and histamine

The American Journal of Pathology
S D BamforthJ Greenwood

Abstract

The vascular barriers of the central nervous system form a selective cellular interface between the blood and the neural parenchyma and restrict the transfer of both molecules and hematogenous cells. During immune-mediated diseases, leukocyte infiltration becomes dramatically up-regulated and the permeability of these barriers increases, leading to edema formation. The etiology of this damage remains largely unresolved although inflammatory cytokines have been implicated in the process. The effect of the proinflammatory cytokine interleukin (IL)-1 beta on the integrity of the rat blood-retinal barrier (BRB) was investigated up to 14 days after an intravitreal injection. The permeability of the BRB was evaluated quantitatively using the low molecular weight tracer [14C]mannitol. After IL-1 beta administration, a biphasic opening of the BRB to [14C]mannitol was recorded, peaking at 4 to 8 hours and 24 to 48 hours post-injection (PI). The early disruption coincided with the appearance of both polymorphonuclear and mononuclear leukocytes within the retina. By 12 hours PI, BRB permeability had returned to control values despite a continued increase in the number of infiltrating leukocytes. The second, more pronounced increase in bar...Continue Reading

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