PMID: 7525939Nov 1, 1994Paper

Interleukin-1 beta inhibits synaptic transmission and induces membrane hyperpolarization in amygdala neurons

The Journal of Pharmacology and Experimental Therapeutics
B Yu, P Shinnick-Gallagher

Abstract

Interleukin-1 beta (IL-1 beta), a mediator of immune response, is found in the brain and IL-1 binding sites are located in the basolateral amygdala (BLA). Superfusion of IL-1 beta (118 pM) hyperpolarized the membrane and decreased input resistance in most BLA neurons in brain slice preparations. The hyperpolarization was dose dependent, reversible, persisted in tetrodotoxin and had an estimated EC50 of 15.3 pM. Reversal potentials for the hyperpolarization recorded with potassium acetate and KCl electrodes were -74 and -40 mV, respectively. These data suggest involvement of a chloride conductance. The hyperpolarization was not observed in bicuculline or in acutely dissociated BLA neurons, which implicates an indirect mediation through enhancement of endogenous gamma-aminobutyric acid (GABA). Superfusion of IL-1 beta (118 pM) inhibited excitatory and fast and slow inhibitory postsynaptic potentials evoked by stimulating either the stria terminalis or the lateral amygdala. Fast and slow inhibitory postsynaptic potentials elicited by direct stimulation of GABA interneurons in the lateral amygdala were also depressed by IL-1 beta. IL-1 beta did not depress responses to GABA or glutamate receptor agonists in slices or currents induc...Continue Reading

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.