Interleukin-1 beta is more potent than interleukin-1 alpha in suppressing follicle-stimulating hormone-induced differentiation of ovarian granulosa cells

Biochemical and Biophysical Research Communications
P E GottschallA Arimura

Abstract

Most studies have shown that the immune and inflammatory actions of interleukin-1 alpha and beta exhibit the identical biological spectrums of activity with similar dose-response curves. We have previously demonstrated that interleukin-1 beta suppresses follicle-stimulating hormone-induced differentiation of ovarian granulosa cells. In these experiments, we show that although the human recombinant preparations of interleukin-1 alpha and beta exhibit a similar directional inhibition of ovarian granulosa cell differentiation, there is a significant difference in the dose-response relationships between the two forms. Interleukin-1 beta was 31 times and 18 times more potent than interleukin-1 alpha in suppressing follicle-stimulating hormone-induced luteinizing hormone receptor development and progesterone secretion, respectively, from rat granulosa cells. However, there was no difference in the dose-dependent activities of interleukin-1 alpha and beta in stimulating murine thymocyte proliferation. These results suggest that interleukin-1 beta is more effective in influencing ovarian granulosa cell function than interleukin-1 alpha.

Citations

Oct 1, 1992·Journal of Assisted Reproduction and Genetics·P A Bergh, D Navot
Nov 28, 1997·Journal of Reproductive Immunology·E Y Adashi
Aug 29, 1998·Molecular and Cellular Endocrinology·E Y Adashi
Dec 1, 1991·American Journal of Reproductive Immunology : AJRI·N AzadN V Emanuele
Mar 1, 1996·American Journal of Reproductive Immunology : AJRI·E Y Adashi
Sep 2, 2006·Reproductive Biology and Endocrinology : RB&E·Simon MacKenzieJosep V Planas
Jan 15, 1993·Biological Psychiatry·M A Cowen, M Green
Dec 1, 1991·Baillière's Clinical Endocrinology and Metabolism·J K Findlay
Dec 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·B D ClarkC A Dinarello

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