PMID: 7544008Aug 15, 1995Paper

Interleukin 1 beta up-regulates the expression of sulfoglucuronosyl paragloboside, a ligand for L-selectin, in brain microvascular endothelial cells

Proceedings of the National Academy of Sciences of the United States of America
T KandaR K Yu

Abstract

Treatment of cultured bovine brain microvascular endothelial cells (BMECs) with interleukin 1 beta (IL-1 beta), an inflammatory cytokine, was shown to induce the accumulation of sulfoglucuronosyl paragloboside (SGPG), a glycolipid bearing the HNK-1 epitope. This resulted in the attachment of a greater number of human lymphocytes to the treated than to the untreated BMEC monolayers. Attachment of human lymphocytes to the IL-1 beta-activated BMEC cells could be blocked either by incubation of the human lymphocytes with an anti-L-selectin antibody or by application of an anti-SGPG antibody to the BMECs. These results suggest that SGPG may act as an important ligand for L-selectin for the regulation of the attachment of activated lymphocytes and their subsequent invasion into the nervous system parenchyma in inflammatory disorders of the central and peripheral nervous systems.

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Citations

Oct 23, 1997·Journal of Neuroscience Research·T KandaK Ikeda
Jul 1, 1996·Journal of Biomedical Science·Y.C. Lee, R.T. Lee
Oct 1, 1996·Current Opinion in Cell Biology·D DunonB A Imhof
Nov 9, 2000·Progress in Retinal and Eye Research·M Uusitalo, T Kivelä
Mar 6, 2013·The Journal of Experimental Medicine·Shlomo Z Ben-SassonWilliam E Paul
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Aug 9, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Divya SagarPooja Jain
Aug 12, 2006·Journal of Neuroimmunology·Robert B RattsMichael K Racke
Sep 17, 2004·Journal of Neuroscience Research·Takashi KandaHidehiro Mizusawa
Oct 3, 2014·Journal of Glaucoma·Margaret E HuflejtMarko I Vuskovic
Nov 20, 2014·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Michael S HughesFred Hochberg
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Apr 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Petra J G ZwijnenburgA Marceline Van Furth

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