Interleukin-1 Blockade: An Update on Emerging Indications

BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
Anoop MistryJeroen C H van der Hilst

Abstract

Interleukin (IL)-1 is a pro-inflammatory cytokine that induces local and systemic inflammation aimed to eliminate microorganisms and tissue damage. However, an increasing number of clinical conditions have been identified in which IL-1 production is considered inappropriate and IL-1 is part of the disease etiology. In autoinflammatory diseases, gout, Schnitzler's syndrome, and adult-onset Still's disease, high levels of inappropriate IL-1 production have been shown to be a key process in the etiology of the disease. In these conditions, blocking IL-1 has proven very effective in clinical studies. In other diseases, IL-1 has shown to be present in disease process but is not the central driving force of inflammation. In these conditions, including type 1 and 2 diabetes mellitus, acute coronary syndrome, amyotrophic lateral sclerosis, and several neoplastic diseases, the benefits of IL-1 blockade are minimal or absent.

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Citations

Dec 25, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Zi-Cong WuZhi-Ping Wang
Apr 29, 2020·Annual Review of Immunology·Nico GhilardiAndrew C Chan
Dec 14, 2018·Molecular Genetics & Genomic Medicine·Ju QiaoHong-Zhong Jin
Aug 14, 2020·European Journal of Hospital Pharmacy. Science and Practice·Irene Sollano-SanchoBlanca San-Jose-Montano

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Methods Mentioned

BETA
biopsies

Clinical Trials Mentioned

NCT02059291

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