PMID: 6981816Aug 1, 1982Paper

Interleukin 1 can replace the requirement for I-A-positive cells in the proliferation of antigen-primed T cells

Proceedings of the National Academy of Sciences of the United States of America
S K Durum, R K Gershon

Abstract

Antigen-primed T cells have been shown to require I-region-compatible adherent cells, as well as the priming antigen, to proliferate in vitro. We postulated that the Ia-recognition event is required for the T cell to induce secretion of the monokine interleukin 1 (IL 1) from adherent cells; the conventionally held view is that Ia is directly required for T cell activation. Our hypothesis predicts that IL I could replace the requirement for Ia+ cells in T cell proliferation assays in vitro. To test this prediction, we depleted keyhole limpet hemocyanin (KLH)-primed C57BL/6 mouse lymph node cells of I-A+ cells by treating with monoclonal anti-I-Ab and complement. As expected, this treatment eliminated the ability of KLH to provoke a proliferative response by primed T cells. Proliferation was restored by providing exogenous IL 1, but only in conjunction with added KLH. The proliferative response of primed T cells could also be blocked by adding anti-I-Ab to culture, and this inhibition could similarly be reversed by providing IL 1 in the presence of the specific antigen KLH. On the basis of these findings we propose a model of T cell activation and discuss its implications.

References

Sep 1, 1979·European Journal of Immunology·A A AugustinH Cosenza
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Citations

Jan 1, 1985·Archives of Oto-rhino-laryngology·J EbbersK H Vosteen
Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·J B MatthewsS S Prime
Jan 1, 1985·Comparative Immunology, Microbiology and Infectious Diseases·M Fevrier
Apr 1, 1987·Immunopharmacology·Y RocheM A Gougerot-Pocidalo
Jan 1, 1986·International Journal of Immunopharmacology·S E ChristmasM Moore
Jul 1, 1989·Transfusion Medicine Reviews·D Caussy, D N Sauder
Jan 1, 1990·Immunology Today·F S di Giovine, G W Duff
Feb 1, 1986·Immunology Today·J J OppenheimS K Durum
Oct 25, 2011·Developmental and Comparative Immunology·Aina-Cathrine OvergårdSonal Patel
Jan 1, 1983·Immunological Reviews·K L Rock, B Benacerraf
May 1, 1984·European Journal of Immunology·E L Larsson, A Coutinho
Oct 1, 1984·European Journal of Immunology·R Di Pauli, T Brückner
Apr 1, 1984·European Journal of Immunology·U LandegrenH Wigzell

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