Interleukin-1β disturbs the proliferation and differentiation of neural precursor cells in the hippocampus via activation of Notch signaling in postnatal rats exposed to lipopolysaccharide

ACS Chemical Neuroscience
Qiongyu LinYiyu Deng

Abstract

Infectious exposure during the perinatal period may predispose to permanent neurological disorders in later life. Here we investigated whether changes in interleukin-1β (IL-1β) are associated with cognitive dysfunction in later life of septic neonatal rats through suppression of neurogenesis in the hippocampus. Sprague-Dawley rats (1-day old) administered lipopolysaccharide (LPS) showed upregulated expression of IL-1β and IL-1 receptors in the hippocampus. At 28 days of age, rats showed longer escape latencies and decreased numbers of crossings after LPS administration. This was coupled with increased numbers of GFAP+ astrocytes and decreased numbers of NeuN+ cells. The numbers of SOX2+ and DCX+ cells were decreased at 1 and 3d, but was increased at 7 and 14d. The proliferation of SOX2+ cells was inhibited at 1 and 3d, but increased at 7 and 14d. In vitro IL-1β administration suppressed the proliferation of neural progenitor cells (NPCs) in neurospheres derived from the hippocampus. GFAP expression was upregulated in differentiated NPCs treated with IL-1β for 4d, but expression of DCX and MAP2 was decreased. Remarkably, the Notch signaling pathway involved in anti-neurogenic and pro-gliogenic differentiation of NPCs was activat...Continue Reading

References

Jul 1, 1989·Analytical Biochemistry·R E BrownK J Hyland
Nov 1, 1994·Brain Research. Molecular Brain Research·P ParnetK W Kelley
Dec 9, 2000·Developmental Biology·J S Mumm, R Kopan
Jun 2, 2001·Journal of Neurophysiology·J S SnyderJ M Wojtowicz
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Oct 31, 2002·Journal of Neuroscience Research·Michael J Bell, John M Hallenbeck
Dec 16, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wendy PhillipsRoger A Barker
Mar 27, 2007·Cell·Maria Xenia G Ilagan, Raphael Kopan
Sep 4, 2007·Progress in Brain Research·Jack M Parent
Jan 8, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ja Wook Koo, Ronald S Duman
Apr 18, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Leslie CrewsEliezer Masliah
Apr 24, 2008·Development, Growth & Differentiation·Ryoichiro KageyamaTaeko Kobayashi
Mar 14, 2009·Differentiation; Research in Biological Diversity·Felicia Yu Hsuan TengBor Luen Tang
Oct 26, 2010·Brain, Behavior, and Immunity·Raz Yirmiya, Inbal Goshen
Oct 27, 2010·Nature Neuroscience·Dengke K MaHongjun Song
Mar 15, 2011·The European Journal of Neuroscience·Beate WinnerFred H Gage
Nov 11, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Patricia A ZunszainCarmine M Pariante
Dec 21, 2011·Journal of Neurochemistry·Jaclyn M SchwarzStaci D Bilbo
Jan 25, 2012·Molecular and Cellular Neurosciences·Holly F GreenYvonne M Nolan
Sep 27, 2013·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Ian LadranKristen J Brennand
Jun 7, 2015·Journal of Neuroinflammation·Inge C M HooglandDiederik van de Beek
Jul 4, 2017·Journal of Alzheimer's Disease : JAD·Jorge ValeroJoão Oliveira Malva
Mar 17, 2018·Neurology India·Levente MolnárCsilla Molnár

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Astrocytes in Repair & Regeneration

Astrocytes are glial cells found within the CNS and are able to regenerate new neurons. They become activated during CNS injury and disease. The activation leads to the transcription of new genes and the repair and regeneration of neurons. Discover the latest research on astrocytes in repair and regeneration here.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.