Interleukin-1 gene cluster polymorphisms and risk of Alzheimer's disease in Chinese Han population

Journal of Neural Transmission
X-Q LiQ-M Qu

Abstract

Interleukin-1 (IL-1) has been implicated as a key cytokine in Alzheimer's disease (AD) pathogenesis. IL-1 gene polymorphisms, especially IL-1A C((-)889)T polymorphism, have been suggested to be associated with AD risk and onset age. To determine if IL-1 polymorphisms are genetic risk factors for developing AD in Chinese Mainland population, we analyzed IL-1A ((-)889), IL-1B ((-)511) and IL-1RN variable number of tandem repeat (VNTR) polymorphisms in a sample of 145 sporadic AD patients and 181 healthy controls. Our data revealed that the three polymorphisms in IL-1 gene cluster might not play a key role in AD pathogenesis in Chinese Mainland Han population.

Citations

Aug 19, 2008·Cellular and Molecular Neurobiology·Ji-Liang HuYan-Jun Zeng
Aug 1, 2011·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Suk Ling Ma, Linda Chiu Wa Lam
Jan 22, 2008·Neurobiology of Aging·Onofre CombarrosDonald J Lehmann
Oct 6, 2012·American Journal of Alzheimer's Disease and Other Dementias·Saliha Handan YildizEvrim Suna Arikan Terzi

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