PMID: 11930657Apr 5, 2002Paper

Interleukin-1 gene polymorphism disease activity and bone mineral metabolism in rheumatoid arthritis

Chinese Medical Journal
Xiao ZhangR Will

Abstract

To determine whether interleukin-1 alpha and 1 beta gene polymorphism is associated with rheumatoid arthritis disease activity and bone mineral metabolism, and whether there is any relationship between IL-1 beta and rheumatoid arthritis (RA) motif gene. IL-1 gene polymorphisms were analyzed in 65 RA patients who met American College of Radiology (ACR) criteria and 60 controls. From genomic DNA, 2 polymorphisms in each gene for IL1 alpha-889 and IL-1 beta + 3953 were typed by PCR-RFLP and HLA-DRB1 allele typing was also undertaken by PCR-SSOP. Some clinical and laboratory parameters were collected. The allelic frequencies and carriage rates were compared between RA patients and controls and between patients with active and quiescent disease. Comparison was also made between IL-1 polymorphism and parameters of bone mineral metabolism and between patients with the HLA-DRB1 RA motif plus IL-1 beta 2 and patients without the two alleles. Fisher test and the analysis of variance was used to analyze the data. There was no significant difference in the frequency and carriage rate of IL-1 alpha polymorphisms between RA patients and the controls. The beta 2/2 genotype of IL-1 beta was more common in female RA patients compared with contr...Continue Reading

Citations

Feb 10, 2010·Scandinavian Journal of Rheumatology·M Y JungJ-H Chung
Sep 1, 2007·Scandinavian Journal of Rheumatology·L-Y LuP-K Sung
May 20, 2003·British Journal of Haematology·Margaret L MacMillanStella M Davies
Nov 23, 2012·International Journal of Immunogenetics·B PeiC Ding
Sep 18, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Chong-ge YouYi-rong Chen

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