Interleukin-1 gene polymorphisms and chronic periodontitis in adult whites: a systematic review and meta-analysis

Journal of Periodontology
Nadeem Y KarimbuxGordon W Duff

Abstract

Interleukin-1 (IL-1) gene polymorphisms have been associated with increased levels of inflammatory mediators and several inflammatory diseases. Periodontitis is a bacterially induced chronic inflammatory disease that destroys the connective tissues and bone that support the teeth, affects substantial numbers of adults, and has been implicated as a contributing factor in systemic diseases. IL-1 gene polymorphisms, most prominently IL1A (-889), IL1A (+4845), and IL1B (+3954), have been associated with chronic periodontitis (CP) in whites. Since the first report, ≥125 studies have examined IL-1 gene variation in relation to periodontal disease. These studies have produced mixed findings in diverse periodontal phenotypes and in different ethnic groups. One previous meta-analysis has been published on this topic and supported an association between IL-1 genes and periodontitis, but considerable doubt remains about the patient populations in which the association may be of clinical relevance. A systematic review and meta-analysis was conducted in an attempt to clarify whether IL-1 gene variants were associated with well-defined clinical phenotypes of CP in white patients. Study inclusion criteria focused on the analytic framework ori...Continue Reading

References

Sep 1, 1984·Journal of Clinical Periodontology·J Lindhe, S Nyman
May 1, 1994·Journal of Periodontology·D S Preiss, J Meyle
Jan 1, 1997·Journal of Clinical Periodontology·K S KornmanG W Duff
Oct 31, 1998·Journal of Clinical Periodontology·E A GoreG M Galbraith
Dec 10, 1999·Journal of Clinical Periodontology·G M GalbraithJ P Pandey
Dec 22, 1999·Journal of Clinical Periodontology·B EhmkeT F Flemmig
Mar 11, 2000·Journal of Periodontology·M J McDevittK S Kornman
Dec 29, 2000·Journal of Periodontology·B S MichalowiczH A Schenkein
May 15, 2001·Journal of Clinical Periodontology·P N PapapanouG Dahlén
Feb 23, 2002·Journal of Periodontal Research·Marina A RogersPatricia Price
May 7, 2002·Genomics·Martin J H NicklinKen Kornman
Jul 13, 2002·Arthritis and Rheumatism·John LoughlinKay Chapman
Apr 19, 2003·Journal of Clinical Periodontology·Dimitra SakellariAntonis Konstantinidis
Apr 25, 2003·Journal of Periodontology·D T Graves, D Cochran
Aug 28, 2003·Clinical Oral Investigations·Benjamin EhmkeThomas Frank Flemmig
Feb 21, 2004·Journal of Periodontology·Orasa AnusaksathienRawee Teanpaisan
Jun 1, 2005·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Geoffrey C WilliamsVictor J Strecher
Jun 25, 2005·Journal of Periodontology·Néstor J LópezCarlos Y Valenzuela
Sep 27, 2005·Journal of Dental Research·L N BorrellG W Taylor
Nov 24, 2005·Journal of Dental Research·P M BrettM Tonetti
Aug 17, 2006·Journal of Clinical Periodontology·D SakellariA Konstantinidis
Jun 8, 2007·Nature·UNKNOWN Wellcome Trust Case Control Consortium
Aug 23, 2007·Journal of Clinical Periodontology·Judith WagnerGottfried Schmalz
Jan 18, 2008·Journal of Clinical Periodontology·Peter EickholzBernadette Pretzl
May 3, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Alexander P ReinerGail P Jarvik
Aug 5, 2008·Journal of Clinical Periodontology·Georgios K NikolopoulosPantelis G Bagos

❮ Previous
Next ❯

Citations

Aug 30, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Paul J MintzNagy A Habib
Oct 24, 2013·BioMed Research International·Rayyan A Kayal
Jan 28, 2014·DNA and Cell Biology·Keiko TanakaMasashi Arakawa
May 7, 2014·Archives of Oral Biology·Lukasz GilowskiTadeusz Faustyn Krzemiński
May 20, 2014·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Dana T TangRaymond P White
Sep 30, 2014·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Caitlin B L MagrawRaymond P White
Mar 5, 2016·Journal of Oral Biology and Craniofacial Research·Mohammad A JavaidSimon D Tran
Feb 9, 2016·Archives of Oral Biology·Diana M Isaza-GuzmánSergio I Tobón-Arroyave
Jul 23, 2014·Journal of Investigative and Clinical Dentistry·Nikolaos A Chrysanthakopoulos, Panagiotis A Chrysanthakopoulos
Oct 3, 2015·Dental Clinics of North America·Bruno G LoosMarja L Laine
Dec 23, 2015·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Christian KirschneckPiero Römer
Mar 3, 2015·The Journal of the American Dental Association·Thomas M BraunWilliam V Giannobile
Apr 6, 2013·Journal of Clinical Periodontology·Clovis Mariano Faggion, Nikolaos Nikitas Giannakopoulos
Sep 13, 2013·Journal of Clinical Periodontology·Alexander TeumerThomas Kocher
Apr 12, 2013·Periodontology 2000·Robert J Genco, Wenche S Borgnakke
Jun 12, 2013·Journal of Clinical Periodontology·Luigi Nibali
Dec 17, 2014·Geriatrics & Gerontology International·Sumit Gaur, Rupali Agnihotri
Aug 26, 2015·Clinical Oral Investigations·Jamal M SteinStefan Reichert
Oct 17, 2012·The Journal of the American Dental Association·William V Giannobile
Feb 25, 2015·Genetic Testing and Molecular Biomarkers·Vamsi LavuSuresh Ranga Rao
Sep 16, 2016·Contemporary Clinical Dentistry·Magali Silveira Monteiro RibeiroJacyara Maria Brito Macedo
Oct 30, 2016·Archives of Oral Biology·Sleiman Razzouk
Mar 22, 2015·The Libyan Journal of Medicine·Mouna M El JilaniNabil S Enattah
Oct 19, 2016·Journal of Clinical Periodontology·Luigi NibaliAlexandre R Vieira
Dec 10, 2016·British Dental Journal·E KingL Addy
Jun 12, 2013·Journal of Dental Research·W V GiannobileK S Kornman
Aug 2, 2017·Periodontology 2000·Charles M Cobb
Aug 2, 2017·Periodontology 2000·Kenneth S KornmanGordon W Duff
Apr 26, 2014·British Dental Journal·A Hasan, R M Palmer
Nov 28, 2013·Immunity & Ageing : I & a·Manuela IanniFederico Licastro
Dec 12, 2019·Expert Review of Clinical Immunology·Szandra DalmádyRolland Gyulai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.