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Interleukin-1β induces differentiation of human mesenchymal stem cells into osteoblasts via the Wnt-5a/receptor tyrosine kinase-like orphan receptor 2 pathway

Arthritis and Rheumatism

Jun 8, 2012

Koshiro SonomotoYoshiya Tanaka

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Abstract

Mesenchymal stem cells (MSCs) are considered to be a novel tool for the treatment of rheumatoid arthritis (RA) because of their multipotency to differentiate into osteoblasts and chondrocytes, their immunosuppressive effects, and availability. The aim of this study was to assess the mec...read more

Mentioned in this Paper

Biochemical Pathway
RNA, Small Interfering
Core Binding Factor Alpha 1 Subunit
RUNX2 gene
Interleukin-1
Bone Marrow Stromal Cells
WNT5A gene
Chondrocyte
Alkaline Phosphatase Stain Method, Blood or Bone Marrow
Cell Differentiation Process
2
66
Paper Details
References
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  • Citations56
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  • References32
  • Citations56
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Interleukin-1β induces differentiation of human mesenchymal stem cells into osteoblasts via the Wnt-5a/receptor tyrosine kinase-like orphan receptor 2 pathway

Arthritis and Rheumatism

Jun 8, 2012

Koshiro SonomotoYoshiya Tanaka

PMID: 22674197

DOI: 10.1002/art.34555

Abstract

Mesenchymal stem cells (MSCs) are considered to be a novel tool for the treatment of rheumatoid arthritis (RA) because of their multipotency to differentiate into osteoblasts and chondrocytes, their immunosuppressive effects, and availability. The aim of this study was to assess the mec...read more

Mentioned in this Paper

Biochemical Pathway
RNA, Small Interfering
Core Binding Factor Alpha 1 Subunit
RUNX2 gene
Interleukin-1
Bone Marrow Stromal Cells
WNT5A gene
Chondrocyte
Alkaline Phosphatase Stain Method, Blood or Bone Marrow
Cell Differentiation Process
2
66

Feeds With Similar Papers

Immunosuppression

Immunosuppression trends for solid organ transplantation have undergone a perceptible shift over the past decade. Discover the latest research on immunosuppression here.

Related Papers

Arthritis and Rheumatism

Human mesenchymal stem cells inhibit osteoclastogenesis through osteoprotegerin production

Arthritis and RheumatismMarch 2, 2011
Koichi OshitaYoshiya Tanaka
Journal of Tissue Engineering and Regenerative Medicine

Agonism of Wnt-β-catenin signalling promotes mesenchymal stem cell (MSC) expansion

Journal of Tissue Engineering and Regenerative MedicineApril 5, 2013
Michael D Hoffman, Danielle S W Benoit
Paper Details
References
  • References32
  • Citations56
1234
  • References32
  • Citations56
12345...

Download from

Publisher
PubMed
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