PMID: 2495010Mar 1, 1989Paper

Interleukin-1 induces interleukin-1 alpha and interleukin-1 beta gene expression in synovial fibroblasts and peripheral blood monocytes

Arthritis and Rheumatism
B J DaltonW J Johnson

Abstract

Cellular interactions involved in the chronic inflammatory response, characteristic of those found in the joints of rheumatoid arthritis patients, were investigated by examining the effect of interleukin-1 (IL-1), tumor necrosis factor alpha, and gamma-interferon on the regulation of IL-1 gene expression and production by synovial fibroblasts. Biologically active IL-1 was detected in lysates of IL-1-treated rat and human fibroblasts that had been isolated from synovial tissue by collagenase digestion. Northern blot analysis of RNA isolated from these cells revealed the expression of IL-1 alpha and IL-1 beta transcripts. Neither the IL-1 transcripts nor the biologic activity of IL-1 was found in untreated synovial fibroblasts. The messenger RNA induction in synovial cells was followed by a time- and dose-dependent expression of intracellular IL-1 activity. Human monocytes and human skin fibroblasts also responded to IL-1 treatment by producing IL-1-specific transcripts. These observations suggest that IL-1 plays a key role in stimulating immune and inflammatory responses and in sustaining those responses through continued production at sites of inflammation.

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Citations

Oct 1, 1992·European Journal of Biochemistry·K I HulkowerC H Evans
Mar 1, 1996·The Tohoku Journal of Experimental Medicine·T SawaiM Hayashi
Sep 28, 2014·Annals of the Rheumatic Diseases·Eirini ApostolidouKonstantinos Ritis
Feb 2, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yoko TodaYoshiya Tanaka
Dec 25, 2019·Heliyon·Johnathan Abou-FadelJun Zhang

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