Interleukin-1 receptor antagonist (IL1RN) is associated with suppression of early carcinogenic events in human oral malignancies

International Journal of Oncology
Masashi ShiibaH Tanzawa

Abstract

Inflammatory abnormalities have been implicated in the pathogenesis of various human diseases, including cancer. Interleukin-1 receptor antagonist (IL1RN) is a potent anti-inflammatory molecule that modulates the biological activity of the proinflammatory cytokine, interleukin-1. The aim of this study was to examine the expression of IL1RN in oral squamous cell carcinomas (OSCCs), and to determine its clinical significance. Expression levels of IL1RN in matched normal and tumor specimens from 39 OSCCs were evaluated using real-time quantitative polymerase chain reaction methods, and immunohistochemical analysis. Protein expression of IL1RN was also examined in 18 oral premalignant lesions (OPLs). Expression of IL1RN mRNA was significantly downregulated in OSCCs compared with normal tissues. Decreased expression of IL1RN protein was also observed in OPLs and OSCCs. The IL1RN expression level was lower in the OPL cases with severe dysplasia compared to those with mild/moderate dysplasia. Significantly downregulated IL1RN expression was observed in all OSCC lesion sites examined when compared with the matched normal tissues. However, the decreased level of IL1RN expression did not correspond with tumor progression. Noteworthy, IL1...Continue Reading

References

Nov 1, 1991·The Journal of Clinical Investigation·W P Arend
Jan 1, 1989·Advances in Immunology·C A Dinarello
Jun 1, 1997·Scandinavian Journal of Gastroenterology·H IwagakiN Tanaka
Jul 1, 1998·International Reviews of Immunology·C A Dinarello
Nov 14, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·R DewberryS Francis
May 11, 2001·Molecular Carcinogenesis·E LaS M Fischer
Jan 5, 2002·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·R Kurzrock
Sep 11, 2002·Cytokine & Growth Factor Reviews·William P Arend
Apr 16, 2003·Gynecologic Oncology·Ritsuto FujiwakiKohji Miyazaki
May 13, 2003·International Journal of Cancer. Journal International Du Cancer·Ariana ZnaorPaolo Boffetta
Feb 19, 2004·Oral Oncology·Carlo La VecchiaFabio Levi
Jun 19, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Nurija BilalovicEmina E Torlakovic
Feb 21, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dina M ElarajH Richard Alexander
Oct 13, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Dipen J ParekhIan M Thompson
Oct 28, 2008·The Journal of Surgical Research·Yoichi MatsuoSushovan Guha
Aug 12, 2009·Current Opinion in Pharmacology·Bharat B Aggarwal, Prashasnika Gehlot
Oct 13, 2010·Evidence-based Dentistry·Imad Al-Dakkak
Oct 11, 2011·Bioscience Reports·Gautam SethiVinay Tergaonkar

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Citations

May 11, 2021·Frontiers in Oncology·Natarajan BhaskaranPushpa Pandiyan
Jun 3, 2021·International Journal of Molecular Sciences·Lisa SchneiderAxel John

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