Interleukin-1 Receptor-Induced Nitric Oxide Production in the Pancreas Controls Hyperglycemia Caused by Scorpion Envenomation.

Toxins
Mouzarllem Barros ReisLúcia Helena Faccioli

Abstract

Tityus serrulatus causes numerous scorpion envenomation accidents and deaths worldwide. The symptoms vary from local to systemic manifestations, culminating in pulmonary edema and cardiogenic shock. Among these events, transitory hyperglycemia is a severe manifestation that influences pulmonary edema, hemodynamic alterations, and cardiac disturbances. However, the molecular mechanism that leads to increased glucose levels after T. serrulatus envenomation remains unknown. This study aimed to investigate our hypothesis that hyperglycemia due to scorpion envenomation involves inflammatory signaling in the pancreas. The present study showed that T. serrulatus venom induces the production of IL-1α and IL-1β in the pancreas, which signal via IL-1R and provoke nitric oxide (NO) production as well as edema in β-cells in islets. Il1r1-/- mice were protected from transitory hyperglycemia and did not present disturbances in insulin levels in the serum. These results suggest that the pathway driven by IL-1α/IL-1β-IL-1R-NO inhibits insulin release by β-cells, which increases systemic glucose concentration during severe scorpion envenomation. A supportive therapy that inhibits NO production, combined with antiserum, may help to prevent fatal...Continue Reading

References

Jan 1, 1996·Proceedings of the Society for Experimental Biology and Medicine·M L McDanielJ A Corbett
Sep 15, 2010·Toxicon : Official Journal of the International Society on Toxinology·D A C CusinatoE C Arantes
May 10, 2011·Toxicon : Official Journal of the International Society on Toxinology·Karina Furlani ZoccalLúcia Helena Faccioli
Oct 23, 2012·Toxicon : Official Journal of the International Society on Toxinology·Karina Furlani ZoccalLúcia Helena Faccioli
Mar 15, 2014·Acta Cirúrgica Brasileira·Rogério Renato PerezAdriano Miziara Gonzalez
Jul 31, 2014·The New England Journal of Medicine·Geoffrey K Isbister, Himmatrao Saluba Bawaskar
Dec 3, 2014·Toxicon : Official Journal of the International Society on Toxinology·Karina Furlani ZoccalLúcia Helena Faccioli
Jan 1, 2014·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Guilherme Carneiro Reckziegel, Vitor Laerte Pinto
Nov 3, 2015·Toxicon : Official Journal of the International Society on Toxinology·Manuela Berto PuccaGuilherme Honda de Oliveira
Dec 18, 2015·Revista Da Sociedade Brasileira De Medicina Tropical·Palmira Cupo
Sep 24, 2016·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Guilherme Honda de OliveiraManuela Berto Pucca
Oct 5, 2016·JCI Insight·Catherine HajmrlePatrick E MacDonald
Mar 31, 2017·Nature Reviews. Disease Primers·Anastasia KatsarouÅke Lernmark
May 15, 2018·Frontiers in Immunology·Karina F ZoccalLúcia Helena Faccioli
Mar 20, 2019·Frontiers in Pharmacology·Karina F ZoccalLúcia H Faccioli
Jun 23, 2019·Toxicon : Official Journal of the International Society on Toxinology·Mouzarllem Barros ReisLúcia Helena Faccioli

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

GraphPad Prism

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