PMID: 8597415Dec 29, 1995Paper

Interleukin-1 receptors in the brain-endocrine-immune axis. Modulation by stress and infection

Annals of the New York Academy of Sciences
T TakaoE B De Souza

Abstract

In the present study, we examined the in vitro and in vivo modulation of IL-1 receptors by stress and endotoxin treatment. The treatment of AtT-20 mouse pituitary adenoma cells for 24 h with neuroendocrine mediators of stress such as CRF and catecholamines produced dose-dependent increases in cAMP production and [125I]IL-1 alpha binding. In contrast, somatostatin and dexamethasone significantly inhibited CRF-stimulated cAMP production and decreased both basal and CRF-mediated increases in [125I]IL-1 alpha binding. Furthermore, in keeping with the effects of stress mediators to up-regulate IL-1 receptors in AtT-20 cells, ether-laparotomy stress in mice resulted in a significant increase in [125I]IL-1 alpha binding in the pituitary with no significant alterations observed in the brain; in contrast, [125I]oCRF binding in the pituitary was significantly decreased after the ether-laparotomy stress. Next, we investigated the modulation of IL-1 beta levels and [125I]IL-1 alpha binding following endotoxin treatment. IL-1 beta levels were dramatically increased in the peripheral tissues (pituitary, testis, and spleen) at 2-6 h after a single LPS injection (30 micrograms LPS/mouse); however, no significant changes were observed in brain ...Continue Reading

References

May 11, 1991·Endocrinology·E T CunninghamE B De Souza
Jul 1, 1990·Endocrinology·T TakaoE B De Souza
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·L SnyersJ Content
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A P LiebermanM L Shin
Oct 1, 1989·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S B Mizel
Oct 1, 1988·The International Journal of Neuroscience·F A LueH Moldofsky
Oct 1, 1988·Journal of Neuroscience Research·E HetierA Prochiantz
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May 4, 1984·Science·J Axelrod, T D Reisine
Jan 28, 1994·Biochemical and Biophysical Research Communications·L C PayneJ E Blalock
Apr 1, 1993·Pharmacology, Biochemistry, and Behavior·S M AndersonE B De Souza
Feb 1, 1986·Immunology Today·J J OppenheimS K Durum

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Citations

Jul 6, 2014·BioMed Research International·Andrzej P HermanDorota Tomaszewska-Zaremba

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