PMID: 8964915May 1, 1996Paper

Interleukin-1 receptors type I and type II in the mouse brain: kinetics of mRNA expressions after peripheral administration of bacterial lipopolysaccharide

Journal of Neuroimmunology
M M GabellecF Haour

Abstract

The expression of transcripts for Interleukin-1 (IL-1) type I and type II receptors (IL-1R1, IL-1R2) was investigated in the mouse brain and spleen using reverse transcription-polymerase chain reaction techniques under basal conditions and following injection of endotoxin (LPS, i.p., 4 mg/kg). Under basal conditions, mRNAs for both receptor types were found in various parts of the brain, in pituitary as well as in spleen. Following LPS stimulation, mRNA expressions were increased in all studied tissues. IL-1R1 mRNAs were predominant in the brain and pituitary while, IL-1R2 mRNAs were more abundant in the spleen. The maximal quantity of transcripts (IL-1R1, IL-1R2) was obtained 6 h after LPS injection in all studied tissues. The decrease to basal level was observed within 48 h in the brain. In the spleen, IL-1R1 mRNAs remained elevated 48 h after LPS while IL-1R2 mRNAs had already reached basal level. These results indicate a LPS-induced stimulation of IL-1 receptors mRNAs in the brain and a differential expression of IL-1R1 and IL-1R2 transcripts in brain and immune tissues.

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Citations

Aug 5, 2000·Brain Research. Molecular Brain Research·L C ParkerG N Luheshi
Apr 2, 2005·Viral Immunology·Marni N SilvermanAndrew H Miller
Jun 18, 1998·Annals of the New York Academy of Sciences·F HaourT Ternynck
Aug 21, 2013·Clinical & Developmental Immunology·Andrzej Przemysław HermanDorota Tomaszewska-Zaremba
Apr 9, 2005·The European Journal of Neuroscience·Fabian DocagneDaniel C Anthony
Dec 1, 2012·Brain, Behavior, and Immunity·Vanessa A PetersGregory G Freund
Jul 6, 2014·BioMed Research International·Andrzej P HermanDorota Tomaszewska-Zaremba
Feb 20, 2009·The International Journal of Neuropsychopharmacology·Rushaniya A KhairovaHusseini K Manji
Sep 4, 2007·Progress in Brain Research·Mark Pickering, John J O'Connor
Jan 26, 2000·Journal of Neurochemistry·L VitkovicC Jacque
Jan 23, 1999·International Reviews of Immunology·R C Gaillard

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