Interleukin-1 stimulates luteinizing hormone release during the midfollicular phase in the rhesus monkey: a novel way in which stress may influence the menstrual cycle

The Journal of Clinical Endocrinology and Metabolism
E XiaoM Ferin

Abstract

We previously demonstrated an inhibitory effect of an inflammatory/immune-like stress challenge, as simulated by intracerebroventricular interleukin-1 alpha (IL-1 alpha) administration, on LH secretion in the ovariectomized rhesus monkey. This was shown to be the result of activation of the hypothalamo-pituitary-adrenal axis by the cytokine. In the present experiments, we have investigated LH and cortisol responses to IL-1 alpha administration in intact monkeys during the follicular phase of the menstrual cycle. Eleven adult rhesus monkeys, bearing an intraventricular cannula for cytokine administration, were used. Cycle parameters were monitored in the preceding control cycles, during the experimental cycles, as well as in subsequent cycles by daily measurements of estradiol and progesterone concentrations and daily menstruation checks. The experiments were performed according to estradiol concentrations: estradiol, 5-38 pg/mL, group 1, early follicular; and estradiol, 50-64 pg/mL, group 2, midfollicular. The effects of intracerebroventricular saline (30 microL/30 min) or IL-1 alpha (4.2 micrograms/30 min) infusions on LH, FSH, and cortisol were compared. After saline infusion, there was no significant change in LH secretion. ...Continue Reading

Citations

Mar 4, 1998·Proceedings of the National Academy of Sciences of the United States of America·J LicinioP W Gold
May 28, 2010·Reproductive Biology and Endocrinology : RB&E·Juan J TarínAntonio Cano
Jun 28, 2011·American Journal of Physical Anthropology·Kathleen A O'ConnorMarc Tatar

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