Interleukin-1 stimulates the beta-amyloid precursor protein promoter

Cellular and Molecular Neurobiology
R J DonnellyM P Vitek

Abstract

1. Amyloid plaques found in the brains of Alzheimer's diseased patients are composed of the 42 amino acid beta-amyloid peptide (BAP) which is processed out of the larger amyloid precursor protein (APP). 2. To study the regulation of the APP gene expression, we have isolated the promoter region of this angle of this single-copy gene and produced a reporter gene system to determine if the promoter is responsive to agents that may cause the overproduction of APP leading to the abnormal accumulation of plaques in AD. 3. The promoter contains sequences homologous to heat shock elements, AP-1 binding sites, and phorbol ester-inducible sequences as well as GG-rich regions found in other constitutively expressed genes. 4. We show here that this promoter is inducible in cultured cells by interleukin-1 (IL-1) in a transient assay system and that the HSE and AP-1 binding site are required for this inducibility. 5. This induction of transcription from the APP promoter implies that this gene is responsive to tropic and/or trophic agents which may be present in the diseased brain.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Dec 1, 1988·Genes & Development·F J RauscherT Curran
Apr 1, 1989·Trends in Neurosciences·R E TanziJ F Gusella
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D GoldgaberD C Gajdusek
Feb 28, 1989·Biochemical and Biophysical Research Communications·G La FauciN K Robakis
Jan 1, 1989·Progress in Clinical and Biological Research·T DyrksK Beyreuther
Jan 25, 1989·Nucleic Acids Research·H G LemaireB Müller-Hill
Aug 1, 1988·Molecular and Cellular Biology·A SehgalM Chao
Feb 20, 1987·Science·P H St George-HyslopD Drachman
Jul 1, 1988·Neurobiology of Aging·R J DonnellyM Vitek
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·W C MobleyM P McKinley
Feb 12, 1988·Cell·G G Glenner
Nov 4, 1988·Cell·T Curran, B R Franza
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M L CohenS G Younkin
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G A HigginsM C Wilson
Aug 25, 1988·Nucleic Acids Research·C M SaxZ E Zehner

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Citations

Oct 1, 1992·Journal of Neuroscience Research·R M GubitsM P Vitek
Jan 1, 1993·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·H SoininenP J Riekkinen
Jul 18, 2008·Pediatric Surgery International·S W Moore
Nov 30, 2010·Neuroscience Bulletin·Zhen-Bo Huang, Guo-Qing Sheng
May 23, 2012·Neurotoxicity Research·Shohreh MajdWeiping Gai
Apr 1, 1992·Trends in Pharmacological Sciences·M C RoystonG W Roberts
Apr 1, 1994·Brain Research. Molecular Brain Research·M ButtiniH W Boddeke
Jan 1, 1994·European Journal of Pharmacology·C R Plata-Salamán, J M ffrench-Mullen
Feb 13, 2001·Neuroscience and Biobehavioral Reviews·C Rachal PughJ W Rudy
May 14, 1998·Neuroscience and Biobehavioral Reviews·P Malek-Ahmadi
Jun 20, 2000·Neurobiology of Aging·H AkiyamaT Wyss-Coray
Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J D BuxbaumP Greengard
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S L AckermanC Y Yeung
Apr 15, 1999·Annual Review of Neuroscience·F González-Scarano, G Baltuch
Jun 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·K T ShawN H Greig
Mar 25, 2014·Journal of Neuroinflammation·Ian A Clark, Bryce Vissel
Jan 5, 2001·Expert Opinion on Investigational Drugs·M K O'Banion
Nov 13, 1998·Journal of Pharmaceutical Sciences·R J BoadoW M Pardridge
Dec 1, 1992·Journal of Neuroscience Research·L S PerlmutterH C Chui
Oct 21, 2016·Geriatrics & Gerontology International·Melda BozluolcayDildar Konukoglu
Mar 3, 1999·Medical Hypotheses·M F McCarty
Aug 14, 2013·Biochemical Pharmacology·Ian A Clark, Bryce Vissel
Jul 1, 1997·Reviews in the Neurosciences·M DragunowR L Faull
Sep 9, 2011·Neuromolecular Medicine·Zhiyou CaiAnna Ratka
Nov 9, 2019·Current Protein & Peptide Science·Zhe Ying HaKeng Yoon Yeong
Jul 11, 2020·Therapeutic Advances in Neurological Disorders·Olaf StuveBertis B Little
Jun 1, 1995·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·D M Araujo, C W Cotman
Mar 3, 1998·Neurosurgery·S HolminT Mathiesen

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