PMID: 2503616Jul 1, 1989Paper

Interleukin-1 suppresses follicle-stimulating hormone-induced estradiol secretion from cultured ovarian granulosa cells

Journal of Reproductive Immunology
P E GottschallA Arimura

Abstract

The effect of recombinant human interleukin-1 beta (IL-1 beta) on the follicle stimulating hormone-(FSH) induced secretion of estradiol was investigated using cultured granulosa cells obtained from immature rats with diethylstilbestrol implants. Estradiol secretion was significantly reduced by IL-1 beta in cultures containing FSH and either 10(-7) or 10(-8) M androstenedione as a substrate for estradiol synthesis. However, the inhibition of FSH-induced estradiol secretion by IL-1 beta was more apparent in the presence of 10(-8) M as compared to 10(-7) M androstenedione. IL-1 beta suppressed estradiol secretion during a 72 h culture in a dose-dependent manner with a minimum effective dose of 10 ng/ml. The reduction of FSH-stimulated estradiol secretion by IL-1 beta was greatest after a 48 h culture in the presence of 10(-8) M androstenedione. IL-1 beta did not effect estradiol production when cultures were incubated with various doses of androstenedione in the absence of FSH. Finally, IL-1 beta also suppressed the forskolin-induced secretion of estradiol. These results suggest that IL-1 beta may play some role in the multifactorial regulation of aromatase and estrogen secretion in the early developing follicle, and IL-1 beta may...Continue Reading

References

Dec 16, 1987·Biochemical and Biophysical Research Communications·P E GottschallA Arimura
Apr 1, 1987·International Journal of Andrology·S A KhanE M Ritzén
Feb 1, 1987·Fertility and Sterility·H FakihH O Williamson
Jan 1, 1986·Psychoneuroendocrinology·R Zwick
Mar 8, 1985·Science·J G Cannon, C A Dinarello
Jul 1, 1983·Journal of Steroid Biochemistry·D W SchombergJ S Mondschein
May 1, 1984·Molecular and Cellular Endocrinology·J B Davoren, A J Hsueh

❮ Previous
Next ❯

Citations

Nov 28, 1997·Journal of Reproductive Immunology·E Y Adashi
Aug 29, 1998·Molecular and Cellular Endocrinology·E Y Adashi
Nov 1, 1990·American Journal of Reproductive Immunology : AJRI·T Mori
Mar 1, 1996·American Journal of Reproductive Immunology : AJRI·E Y Adashi
Jan 1, 1997·American Journal of Reproductive Immunology : AJRI·P F Terranova, V M Rice
May 18, 1999·American Journal of Reproductive Immunology : AJRI·L L ArnoldB C Mansfield
Aug 13, 2014·Proceedings of the National Academy of Sciences of the United States of America·Shiri Uri-BelapolskyYehuda Kamari
Dec 1, 1991·Baillière's Clinical Endocrinology and Metabolism·J K Findlay
Sep 1, 1992·Journal of Endocrinological Investigation·B S HurstG D Berkovitz
Mar 7, 2021·Genes·Reem SabryLaura A Favetta

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.