Interleukin-10 -1082 promoter polymorphism associated with gastric cancer among Asians

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Yong ZhouXiao-Ting Wu

Abstract

Studies investigating the association between interleukin-10 (IL-10) -1082 promoter polymorphism and gastric cancer risk report conflicting results. The objective of this study was to quantitatively summarise the evidence for such a relationship. Two investigators independently searched the Medline and Embase databases. This meta-analysis included 13 case-control studies, which included 2227 gastric cancer cases and 3538 controls. The combined results based on all studies showed that there was no significant difference in genotype distribution [AA odds ratio (OR)=0.92, 95% confidence interval (CI)=0.73, 1.14; AG (OR=1.09, 95% CI=0.87, 1.36); GG (OR=1.03, 95% CI=0.85, 1.25)] between gastric cancer and noncancer patients. When stratifying for race, results were similar except that patients with gastric cancer had a significantly lower frequency of AA (OR=0.71, 95% CI=0.52, 0.97) and higher frequency AG (OR=1.53, 95% CI=1.15, 2.03) than noncancer patients among Asians. When stratifying by the location of gastric cancer, we found that patients with cardia gastric cancer had a significantly lower frequency of AA (OR=0.53, 95% CI=0.34, 0.83) and higher frequency AG (OR=1.50, 95% CI=1.06, 2.11) than those with noncardia gastric cancer...Continue Reading

References

Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
May 18, 1999·Journal of the National Cancer Institute·S S Devesa, J F Fraumeni
Oct 16, 2001·Nature Genetics·J P IoannidisD G Contopoulos-Ioannidis
Oct 23, 2001·International Journal of Cancer. Journal International Du Cancer·D M ParkinP Pisani
Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·Carlos A GonzálezGabriel Capellá
Feb 21, 2003·International Journal of Cancer. Journal International Du Cancer·Ming-Shiang WuJaw-Town Lin
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Apr 2, 2005·Breast Cancer Research and Treatment·Uwe LangsenlehnerHellmut Samonigg
Jun 28, 2005·Cancer Letters·Ja Young LeeJae Young Yoo
Aug 27, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Chuen-Ming ShihLong-Yau Lin
Jan 18, 2006·Cancer Causes & Control : CCC·Farin KamangarPhilip R Taylor
Jul 6, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Douglas R MorganRobert S Sandler
Jun 5, 2007·International Journal of Cancer. Journal International Du Cancer·Yong ZhouXiao-Ting Wu
Jul 21, 2007·The American Journal of Gastroenterology·María Asunción García-GonzálezUNKNOWN Spanish Gastroenterological Association AEG
Aug 25, 2007·Journal of Gastroenterology and Hepatology·Mitsushige SugimotoAkira Hishida
Nov 14, 2007·Cancer Causes & Control : CCC·Jessica M Faupel-BadgerJoseph A Tangrea
Dec 19, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Sergio A ConTetsuro Sugiura
Feb 19, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Henrike E Karim-KosJan Willem W Coebergh
Mar 28, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P Boyle
May 6, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A GondosUNKNOWN EUNICE Survival Working Group

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Citations

Jun 19, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Wen Feng YanGang Wu
Jun 19, 2010·Japanese Journal of Clinical Oncology·Koji MatsumotoHiroyuki Yoshikawa
Mar 12, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Yelena Y JanjigianManish A Shah
May 2, 2014·World Journal of Gastroenterology : WJG·Juwon KimKyung-A Lee
Sep 19, 2009·Digestive Diseases and Sciences·Hong WangXiao-Ting Wu
Aug 30, 2011·Human Immunology·Arseniy Yuzhalin
Oct 9, 2012·Journal of Surgical Oncology·Yelena Y Janjigian, David P Kelsen
Jun 19, 2013·Radiation Research·Tomonori HayashiKei Nakachi
Nov 18, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Lei GaoHermann Brenner
Jul 3, 2009·Current Opinion in Pharmacology·Mairi H McLean, Emad M El-Omar
Jun 23, 2012·Digestive Diseases·Marcis LejaPeter Malfertheiner
Sep 11, 2018·Journal of Cancer Research and Therapeutics·Reham RashedHanan E Shafik
Oct 19, 2010·Molecular and Cellular Biochemistry·Yong ZhouXiaoting Wu
Jun 4, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Chen-Jiao YaoZi-Li Fan
Jun 26, 2020·Frontiers in Immunology·Zhonghua ZhengShiwei Duan
May 10, 2011·Molecular Biology Reports·Yu ZhuHai-Feng Pan
Apr 26, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Fen ZhaoYing Huang
Mar 5, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Bárbara PeleteiroHenrique Barros
Mar 25, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rita A BusuttilAlex Boussioutas
Jun 18, 2021·Canadian Journal of Gastroenterology & Hepatology·Md ZeyaullahIrfan Ahmad

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