PMID: 9184265May 1, 1997Paper

Interleukin-10 and interleukin-6 in lupus erythematosus and rheumatoid arthritis, correlations with acute phase proteins

Clinical Rheumatology
J K LackiS H Mackiewicz

Abstract

We sought to investigate the influence of interleukin-10 (IL-10) and IL-6 on the acute phase proteins (APP) in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). IL-10, IL-6, Creactive protein (CRP), alpha-1-acid glycoprotein (AGP), and alpha1 antichymotrypsin (ACT) serum levels were determined in one hundred-eight patients (71 with SLE, 37 with RA). Quantification of the serum IL-10 level showed increased levels in SLE and RA patients as compared to healthy controls. Serum IL-6 level was found to be elevated in SLE and RA patients. A correlation between IL-10 and IL-6 serum level was found only in SLE. CRP and AGP serum levels were increased in RA as compared to controls, whereas in SLE only AGP was found elevated. A statistically significant correlation between IL-6 serum level and CRP, AGP and ACT was found only in RA. No correlation between IL-10 and serum level of CRP, AGP and ACT was established. Since IL-10 has a potent immunosuppressive activity, we expected it to be negatively correlated with APP levels. Surprisingly, IL-10 did not correlate with APP either in SLE or RA patients. However, the elevation of IL-10 serum levels in SLE and RA and the correlation between IL-10 and IL-6 in SLE may suggest that ...Continue Reading

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Citations

May 28, 2013·Clinical Rheumatology·Hui PengDong-Qing Ye
Oct 6, 2010·Journal of Clinical Immunology·Aharon KesselElias Toubi
Jun 7, 2003·Journal of Autoimmunity·Luis Llorente, Yvonne Richaud-Patin
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Mar 16, 2012·Arthritis Research & Therapy·Andrea DoriaMichelle Petri
Jul 14, 2010·Journal of Biomedicine & Biotechnology·Patricia LópezAna Suárez
Oct 17, 2014·Immunopharmacology and Immunotoxicology·Fahimeh Lavi ArabMahmoud Mahmoudi
Aug 10, 2001·Drug Metabolism Reviews·Z H Israili, P G Dayton
Jan 22, 2008·Seminars in Arthritis and Rheumatism·Arlene T Tieng, Elena Peeva
Nov 28, 2008·Arthritis and Rheumatism·Shilpa GaitondeIrving Kushner
Jan 29, 2002·Best Practice & Research. Clinical Rheumatology·M Piecyk, P Anderson
Aug 6, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Jiali ZhuZhenghong Qin
Oct 7, 2016·Scientific Reports·Jack GodsellJames Harris
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