Interleukin-10 and tumour necrosis factor-alpha serum levels in chronic Chagas disease patients

Parasite Immunology
Romero H T VasconcelosYara M Gomes

Abstract

In Chagas disease, chronically infected individuals may be asymptomatic or may present cardiac or digestive complications, and it is well known that the human immune response is related to different clinical manifestations. Different patterns of cytokine levels have been previously described in different clinical forms of this disease, but contradictory results are reported. Our aim was to evaluate the serum levels of interleukin-10 and tumour necrosis factor-alpha in patients with asymptomatic and cardiac Chagas disease. The serum interleukin-10 levels in patients with cardiomyopathy were higher than those in asymptomatic patients, mainly in those without heart enlargement. Although no significant difference was observed in serum tumour necrosis factor-alpha levels among the patients, we found that cardiac patients also present high levels of this cytokine, largely those with heart dilatation. Therefore, these cytokines play an important role in chronic Chagas disease cardiomyopathy. Follow-up investigations of these and other cytokines in patients with chronic Chagas disease need to be conducted to improve the understanding of the immunopathology of this disease.

References

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Citations

Sep 17, 2016·Asian Pacific Journal of Tropical Medicine·Áurea Regina Telles PupulinCiomar Aparecida Bersani-Amado
Dec 7, 2017·Frontiers in Immunology·Melisa Gorosito SerránAdriana Gruppi
Aug 3, 2017·Molecular and Cellular Biochemistry·Aniélen D SilvaAleksandro S Da Silva
Mar 29, 2018·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M C SilvaA Talvani

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