Interleukin-10-dependent down-regulation of interferon-gamma response to Leishmania by Mycobacterium leprae antigens during the clinical course of a coinfection.

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
R B G Azeredo-CoutinhoS C Mendonca

Abstract

We have described a case of a patient with an intriguing association of mucocutaneous leishmaniasis with lepromatous leprosy, two opposite polar forms of these spectral diseases. In the present follow-up study, we investigated the effect of the addition of Mycobacterium leprae antigens on interferon-gamma (IFN-γ) production in Leishmania antigen-stimulated cultures of peripheral blood mononuclear cells (PBMC) from this patient. For this purpose, PBMC cultures were stimulated with crude L. braziliensis and/or M. leprae whole-cell antigen extracts or with concanavalin A. In some experiments, neutralizing anti-human interleukin (IL)-10 antibodies were added to the cultures. IFN-γ and IL-10 levels in culture supernatants were measured by ELISA. During active leprosy, M. leprae antigens induced 72.3% suppression of the IFN-γ response to L. braziliensis antigen, and this suppression was abolished by IL-10 neutralization. Interestingly, the suppressive effect of M. leprae antigen was lost after the cure of leprosy and the disappearance of this effect was accompanied by exacerbation of mucosal leishmaniasis. Considered together, these results provide evidence that the concomitant lepromatous leprosy induced an IL-10-mediated regulatory...Continue Reading

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Citations

Mar 2, 2018·PLoS Neglected Tropical Diseases·Dalila Y MartínezMarleen Boelaert
Jan 6, 2015·International Journal of Dermatology·Deepashree DaulatabadSonal Sharma
Oct 17, 2017·The American Journal of Tropical Medicine and Hygiene·Lucrecia Acosta SotoHelen D Donoghue
Apr 18, 2019·Revista Da Sociedade Brasileira De Medicina Tropical·Sebastian VernalAna Maria Roselino

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Methods Mentioned

BETA
biopsy
ELISA

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