PMID: 9184647Jun 1, 1997Paper

Interleukin-10 downregulates the intracerebral immune response in chronic Toxoplasma encephalitis

Journal of Neuroimmunology
M Deckert-SchlüterD Schlüter

Abstract

The expression of the immunosuppressive cytokine interleukin (IL)-10 in the normal and Toxoplasma gondii-infected murine brain was analysed. Microglia/macrophages expressed IL-10 at the mRNA and protein level in the normal brain. In Toxoplasma encephalitis (TE), CD4+ and CD8+ T-cells also contributed to the upregulated IL-10 production. Neutralization of endogenous IL-10 in chronic TE reduced the intracerebral parasitic load and increased the number of immune cells and the production of protective cytokines. These findings indicate that intracerebral expression of IL-10 interferes with the immune response in TE and may contribute to parasite persistence in the brain.

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Citations

Sep 8, 2012·Seminars in Immunopathology·Christopher D DupontChristopher A Hunter
Sep 4, 2009·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Monica M Mariani, Tammy Kielian
May 18, 2000·Journal of Neuroimmunology·Y KitamuraP J Gebicke-Haerter
Apr 18, 2002·Journal of Neuroimmunology·Takashi TogoKenji Kosaka
May 11, 1999·Parasitology Today·C Bogdan, M Röllinghoff
Dec 19, 2000·Scandinavian Journal of Immunology·M E Sarciron, A Gherardi
Oct 19, 2004·Clinical Microbiology Reviews·R Bryan RockPhillip K Peterson
Jun 15, 2011·Immunotherapy·Rajarshi BhadraImtiaz A Khan
Nov 19, 2013·Acta Neuropathologica·Martina DeckertReiner Siebert
Jan 30, 2014·Annual Review of Immunology·Debasis NayakDorian B McGavern
Jul 12, 2005·Journal of Neuroimmunology·Emma H WilsonChristopher A Hunter
Jul 16, 2015·Journal of Immunological Methods·Cristina da Silva MeiraUNKNOWN Toxoplasma Group
Jul 9, 2011·The Korean Journal of Parasitology·Ho-Woo NamHyun-Jong Yang
May 12, 2009·Memórias do Instituto Oswaldo Cruz·Justus G Garweg, Ermanno Candolfi
Mar 15, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Katarzyna A CieslikGeorge E Taffet
Jan 22, 2005·Nature Reviews. Immunology·Julio Aliberti
Dec 2, 2005·Journal of Neuropathology and Experimental Neurology·Werner StenzelMartina Deckert
Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Seon-Kyeong Kim, John C Boothroyd
Mar 16, 2019·Frontiers in Immunology·Dirk Schlüter, Antonio Barragan
Feb 26, 2020·Food and Waterborne Parasitology·Neda KonstantinovicFlorence Robert-Gangneux
Nov 13, 2020·Frontiers in Cellular and Infection Microbiology·Debanjan MukhopadhyayJeroen P J Saeij
Jun 29, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Julio Aliberti, Andre Bafica

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