Interleukin-10 gene polymorphisms influence the clinical course of non-Hodgkin's lymphoma

Tissue Antigens
K Bogunia-KubikA Lange

Abstract

The pathophysiology of Non-Hodgkin's lymphoma (NHL) is still unknown and clinical course is very unpredictable. Many cytokines, including interleukin-10 (IL-10), play a role in the perpetuation of this disease. The IL-10-producing capability has been found to be influenced by the IL-10 gene promoter polymorphisms. The aim of the present study was to assess whether any of IL-10 (-1082 A/G, -819 C/T and -592 A/C) genotypes prevails in Polish patients with NHL and whether IL-10 promoter polymorphisms may be associated with less or more favourable course of the disease. IL-10 gene promoter polymorphisms were assessed in 105 individuals, including 55 NHL patients and 50 ethically matched controls. The frequency of the IL-10 low-producing -1082 AA homozygous genotype was significantly higher in patients with aggressive NHL as compared with patients with indolent forms of the disease (0.57 vs 0.28, P < 0.05) and controls [0.57 vs 0.32, odds ratio (OR) = 2.69, P < 0.05]. Also, the presence of the ACC genotype was more frequently detected among patients with more aggressive disease than in those with indolent forms (0.74 vs 0.47, P < 0.05) and healthy controls (0.74 vs 0.42, OR = 3.69, P < 0.05). In multivariate analyses, the AA homozyg...Continue Reading

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Citations

Sep 3, 2013·BioMed Research International·Tomasz WróbelKatarzyna Bogunia-Kubik
Dec 17, 2009·Ocular Immunology and Inflammation·Chi-Chao ChanBahram Bodaghi
Jun 6, 2015·Leukemia & Lymphoma·Kaspar Rene NielsenHans Erik Johnsen
Jun 11, 2009·European Journal of Haematology·Elisabeth AndrieEleni Th Petridou
Jun 26, 2013·Environmental and Molecular Mutagenesis·Bryan A BassigQing Lan
Dec 12, 2012·Genes, Chromosomes & Cancer·Ewa Lech-MarandaKrzysztof Warzocha
May 29, 2013·Cytokine·Grzegorz MazurKatarzyna Bogunia-Kubik

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