Interleukin-10 (IL-10) but not Lipopolysaccharide (LPS) produces increased motor activity and abnormal exploratory patterns while impairing spatial learning in Balb/c mice

Physiology & Behavior
Deirdre HarveyS Commins

Abstract

Lipopolysaccharide (LPS) is a potent endotoxin, which produces "sickness behaviours" including loss of weight, loss of interest in food and decreased exploration. LPS has also been shown in some studies to cause deficits in various learning and memory abilities, while in others these LPS-induced learning impairments have been attributed to performance-related deficits rather than learning deficits per se. Here, we use the novelty-preference paradigm, a task that minimises performance-related factors such as motivation, in an attempt to extract and examine the effects of LPS on spatial learning. In addition, some studies have indicated that the anti-inflammatory cytokine Interleukin-10 (IL-10) can alleviate some of the symptoms induced by LPS. Here, we also examine the effect of IL-10 on feeding, motor and learning behaviours. We demonstrate that a single injection of LPS does produce a lack of interest in food and weight loss; LPS, however, does not impair habituation in the novelty-preference paradigm. Furthermore, co-injection of IL-10 with LPS does not attenuate the LPS-induced effects of weight loss and lack of food intake. Interestingly, a single injection of IL-10 produces abnormal patterns of exploration, a general incre...Continue Reading

References

Jan 1, 1992·Trends in Pharmacological Sciences·S KentR Dantzer

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Citations

Nov 26, 2009·Cardiovascular Psychiatry and Neurology·Susana RoqueNuno Sousa
Apr 14, 2009·Pharmacology, Biochemistry, and Behavior·Andrew J LockeyKlaus-Peter Ossenkopp
Apr 9, 2008·Journal of Psychiatric Research·Ana Raquel MesquitaNuno Sousa
Aug 18, 2020·Journal of Molecular Neuroscience : MN·Elvira KamaltdinovaVladimir Arkhipov
Jul 28, 2020·Frontiers in Cellular and Infection Microbiology·Zhongyi ZhaoChuanmin Tao
Dec 15, 2020·Neuroscience and Biobehavioral Reviews·Felipe Figueredo SaviCristiane Ritter

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