PMID: 9449724Mar 21, 1998Paper

Interleukin 10 increases CCR5 expression and HIV infection in human monocytes

The Journal of Experimental Medicine
S SozzaniAlberto Mantovani

Abstract

The immunosuppressive and antiinflammatory cytokine interleukin (IL) 10 selectively upregulates the expression of the CC chemokine receptors CCR5, 2, and 1 in human monocytes by prolonging their mRNA half-life. IL-10-stimulated monocytes display an increased number of cell surface receptors for, and better chemotactic responsiveness to, relevant agonists than do control cells. In addition, IL-10-stimulated monocytes are more efficiently infected by HIV BaL. This effect was associated to the enhancement of viral entry through CCR5. These data add support to an emerging paradigm in which pro- and antiinflammatory molecules exert reciprocal and opposing influence on chemokine agonist production and receptor expression.

References

Jul 11, 1986·Science·S GartnerM Popovic
Aug 15, 1995·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·D WeissmanA S Fauci
May 19, 1995·The Journal of Biological Chemistry·A Ben-BaruchJ J Oppenheim
Jan 1, 1994·Annual Review of Immunology·P M Murphy
Jan 1, 1994·Annual Review of Immunology·C Gerard, N P Gerard
Nov 1, 1996·Nature Medicine·B A Premack, T J Schall
Sep 1, 1996·The Journal of Experimental Medicine·C R Mackay
Mar 3, 1997·The Journal of Experimental Medicine·A SicaA Mantovani
Jan 1, 1997·Annual Review of Immunology·M BaggioliniB Moser
May 1, 1996·Current Opinion in Hematology·K Geissler

❮ Previous
Next ❯

Citations

Apr 11, 2006·Clinical & Developmental Immunology·Mette EjrnaesUrs Christen
Dec 13, 2006·Clinical & Developmental Immunology·Mette EjrnaesUrs Christen
May 6, 1999·European Journal of Immunology·C LapentaS Fais
Feb 9, 2008·Medical Microbiology and Immunology·Ann E CampbellJacquelyn S Slater
Mar 5, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Peter J GaskillJoan W Berman
Jun 21, 2005·Cytokine & Growth Factor Reviews·Silvano Sozzani
Mar 17, 2004·Journal of Neuroimmunology·Sergey G KremlevCharles Palmer
Apr 25, 2003·Biochemical and Biophysical Research Communications·Hui LiW S Fred Wong
May 17, 2000·Pharmaceutica acta Helvetiae·S SozzaniA Mantovani
May 4, 2001·Journal of Reproductive Immunology·I AthanassakisS Vassiliadis
Jul 29, 1999·Immunology Letters·A KalinkovichZ Bentwich
Jun 4, 1999·Immunology Today·A Mantovani
Dec 16, 1998·Research in Immunology·A MantovaniS Sozzani
Feb 15, 2001·Trends in Microbiology·S RedpathN R Gascoigne
Oct 23, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Travis S HughesLeslie A Leinwand
Jan 11, 2007·Immunology and Cell Biology·Tsuyoshi YoshidaFujio Suzuki
Aug 4, 2001·The Biochemical Journal·M LocatiS Sozzani
Oct 29, 1998·British Journal of Haematology·C PastoreG Saglio
Mar 6, 2002·Clinical and Experimental Immunology·R ZamarchiA Amadori
Dec 15, 2010·Proceedings of the National Academy of Sciences of the United States of America·W L William Chang, Peter A Barry
Jul 9, 2008·The Journal of Infectious Diseases·D-Y OhR R Schumann
Aug 5, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·R P DonnellyD S Finbloom
Mar 7, 2000·Clinical and Diagnostic Laboratory Immunology·G M Graziani-Bowering, L G Filion
Jan 25, 2005·Infection and Immunity·Maria Jania TeixeiraAldina Barral
Mar 13, 2001·Annual Review of Immunology·K W MooreA O'Garra
Mar 23, 2004·Annual Review of Immunology·Sidney PestkaPaul B Fisher

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.