Interleukin-10 levels in rat models of nerve damage and neuropathic pain

Neuroscience Letters
Junad KhanE Eliav

Abstract

Interleukin-10 (IL-10) is an anti-inflammatory cytokine that has been shown to play a role in inflammatory and autoimmune disorders as well as in neuropathic pain conditions. The objective of the present study was to assess the levels of IL-10 in rat's dorsal root ganglion (DRG) and the sciatic nerve following four different forms of sciatic nerve injury. The models used to induce the injury included two models of partial nerve injury: partial sciatic ligation (PSL) and chronic constriction injury (CCI), a model of complete sciatic transection (CST) and a model of perineural inflammation with minimal nerve damage (neuritis). Withdrawal responses for mechanical stimulus and withdrawal latency for thermal stimulation were used to measure mechanical and thermal hyperalgesia, respectively, and duration of the nociceptive withdrawal reflex to mechanical stimulus was used to measure mechanical hyperalgesia. The affected and contra-lateral nerves and the affected side DRG IL-10 levels were assessed by the means of enzyme-linked immunosorbent assay (ELISA), 3 and 8 days following the procedure and were compared to naïve rats' IL-10 levels. The rats exposed to CCI and neuritis developed significant mechanical and thermal hyperalgesia as...Continue Reading

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Citations

Feb 16, 2016·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Junad KhanVincent Ziccardi
Dec 13, 2017·Scandinavian Journal of Pain·Alice L HungTina L Doshi
Aug 12, 2017·Critical Reviews in Food Science and Nutrition·Hamid MollazadehAmirhossein Sahebkar
Feb 13, 2020·Frontiers in Immunology·Miriam M FonsecaThiago M Cunha
Jun 15, 2017·Scientific Reports·Takumi FujitaTakahiro Takano
Jan 11, 2020·Frontiers in Immunology·Arden G Vanderwall, Erin D Milligan
Aug 22, 2018·Neural Regeneration Research·Meng-Qiang HuangYun-Qiang Xu
Jul 17, 2020·Neuroscience Letters·Camila Lino de OliveiraAndressa de Souza
Feb 24, 2021·The Journal of Clinical Investigation·Mariaconcetta DuranteDaniela Salvemini
May 14, 2021·Pain Reports·Conceição Elidianne Aníbal SilvaThiago Mattar Cunha
May 10, 2019·Archives of Oral Biology·Junad KhanEli Eliav

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