PMID: 8603006Feb 1, 1996Paper

Interleukin-10 mRNA expression in B-cell chronic lymphocytic leukaemia inversely correlates with progression of disease

British Journal of Haematology
J SjöbergP Pisa

Abstract

Interleukin-10 (IL-10) has been shown in vitro to inhibit survival and spontaneous DNA synthesis in B-cell chronic lymphocytic leukaemia (B-CELL) cells by induction of programmed cell death. We have analysed the presence of mRNA transcripts for IL-10 in purified B-CLL cells from 35 patients by RT-PCR. Transcripts for IL-10 were detected in 11/20 patients with non-progressive disease. In cell preparations from patients with progressive B-CLL IL-10 mRNA were detected in only 2/15 samples (P < or = 0.01). The Epstein-Barr virus status of the cells did not account for the difference in IL-10 mRNA expression observed between the two groups of patients. Thus, IL-10 mRNA expression in leukaemic cells from patients with B-CLL was strongly associated with non-progressive disease. This finding may support other observations suggesting that IL-10 might be a candidate for immune therapy of progressive B-CLL.

Citations

Aug 31, 2002·Hematological Oncology·Gerassimos A PangalisMaria K Angelopoulou
Jan 5, 2000·Medical Oncology·M Aguilar-SantelisesM Jondal
Apr 21, 1998·Critical Reviews in Oncology/hematology·J Jurlander
Mar 13, 2001·Annual Review of Immunology·K W MooreA O'Garra
Oct 15, 1996·The Journal of Clinical Investigation·S RamachandraE Raveche
Sep 25, 2010·Leukemia Research·Jason A DubovskyJavier A Pinilla-Ibarz
Aug 15, 2006·Immunological Reviews·Maria Grazia RoncaroloMegan K Levings
Oct 29, 2003·Cytometry. Part B, Clinical Cytometry·A GallegoA Durántez
Aug 7, 2001·Reviews in Clinical and Experimental Hematology·E OrsiniR Foa
May 30, 2003·Pharmacological Reviews·K AsadullahH D Volk
Aug 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F Caligaris-Cappio, T J Hamblin

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.