Interleukin-10 of red nucleus plays anti-allodynia effect in neuropathic pain rats with spared nerve injury.

Neurochemical Research
Zhi-Hong WangJun-Yang Wang

Abstract

Our previous studies have shown that pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-α) and interleukin-1beta (IL-1β) in red nucleus (RN) are involved in the development of neuropathic pain and play facilitated roles on the mechanical allodynia induced by peripheral nerve injury. The current study was designed to evaluate the expression and effect of IL-10, an anti-inflammatory cytokine, in the RN of rats with spared nerve injury (SNI). Immunohistochemical staining results demonstrated when 3 weeks after SNI, the expression level of IL-10 in the contralateral RN of SNI rats was apparently higher than those of sham-operated and normal rats. To further study the effect of IL-10 in the development of neuropathic pain, different doses of IL-10 (1.0, 0.5 and 0.1 μg/μl) were microinjected respectively into the RN contralateral to the nerve injury side of SNI rats. Results demonstrated that higher doses of IL-10 (1.0 and 0.5 μg/μl) significantly attenuated the mechanical allodynia of neuropathic rats, while 0.1 μg/μl of IL-10 did not show any analgesic effect. These results suggest that IL-10 of RN participates in the development of neuropathic pain and plays inhibitory roles on the mechanical allodynia induced by SNI.

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Citations

Dec 18, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Paola SacerdoteAlberto E Panerai
May 28, 2013·Brain Research Bulletin·Yoshihide SatohShin-ichi Iwasaki
Dec 17, 2015·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Jing WangJun-Yang Wang
Oct 21, 2014·Annals of Clinical and Translational Neurology·Thiago D NascimentoAlexandre F DaSilva
Feb 26, 2015·Experimental Physiology·Sergio M BorghiWaldiceu A Verri
Dec 3, 2014·Neuropharmacology·A J KwilaszL R Watkins
Jan 27, 2015·Neurochemical Research·Qingdong ShaoJianning Zhao
Apr 12, 2019·Frontiers in Cellular Neuroscience·Zhongya WeiGang Chen
Nov 13, 2020·Brain Structure & Function·Gianpaolo Antonio BasileAlberto Cacciola

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