Interleukin-10 Produced by Myeloid-Derived Suppressor Cells Provides Protection to Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 258 by Enhancing Its Clearance in the Airways

Infection and Immunity
Hernán F PeñalozaSusan M Bueno

Abstract

Carbapenem-resistant Klebsiella pneumoniae sequence type 258 (CRKP-ST258) can cause chronic infections in lungs and airways, with repeated episodes of bacteremia. In this report we addressed whether the recruitment of myeloid cells producing the anti-inflammatory cytokine interleukin-10 (IL-10) modulates the clearance of CKRP-ST258 in the lungs and establishes bacterial persistence. Our data demonstrate that during pneumonia caused by a clinical isolate of CRKP-ST258 (KP35) there is an early recruitment of monocyte-myeloid-derived suppressor cells (M-MDSCs) and neutrophils that actively produce IL-10. However, M-MDSCs were the cells that sustained the production of IL-10 over the time of infection evaluated. Using mice unable to produce IL-10 (IL-10-/-), we observed that the production of this cytokine during the infection caused by KP35 is important to control bacterial burden, to prevent lung damage, to modulate cytokine production, and to improve host survival. Importantly, intranasal transfer of bone marrow-derived M-MDSCs from mice able to produce IL-10 at 1 day prior to infection improved the ability of IL-10-/- mice to clear KP35 in the lungs, decreasing their mortality. Altogether, our data demonstrate that IL-10 produc...Continue Reading

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Citations

Sep 5, 2019·Infection and Immunity·Marjolaine Vareille-DelarbreChristiane Forestier
May 19, 2020·The Journal of Clinical Investigation·Anca DorhoiNelita du Plessis
Dec 8, 2020·Frontiers in Cellular and Infection Microbiology·Hernán F PeñalozaSusan M Bueno
Dec 17, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Matthew S GodwinChad Steele
Feb 10, 2021·Infection and Immunity·Shekina Gonzalez-FerrerDaria Van Tyne
Mar 28, 2021·Particle and Fibre Toxicology·Christopher T MigliaccioAndrij Holian
May 14, 2021·Cellular Immunology·Hadas Ashkenazi-PreiserMichal Baniyash
Jun 8, 2021·Indian Journal of Microbiology·Lihui ZhaoDonghai Zhang
Sep 3, 2021·PLoS Pathogens·Hernán F PeñalozaPrabir Ray
Dec 2, 2021·International Immunology·Visai Muruganandah, Andreas Kupz

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