Interleukin-10-producing CD5+ B cells inhibit mast cells during immunoglobulin E-mediated allergic responses

Science Signaling
Hyuk Soon KimWahn Soo Choi

Abstract

Subsets of B cells inhibit various immune responses through their production of the cytokine interleukin-10 (IL-10). We found that IL-10-producing CD5(+) B cells suppressed the immunoglobulin E (IgE)- and antigen-mediated activation of mast cells in vitro as well as allergic responses in mice in an IL-10-dependent manner. Furthermore, the suppressive effect of these B cells on mast cells in vitro and in vivo depended on direct cell-to-cell contact through the costimulatory receptor CD40 on CD5(+) B cells and the CD40 ligand on mast cells. This contact enhanced the production of IL-10 by the CD5(+) B cells. Through activation of the Janus-activated kinase-signal transducer and activator of transcription 3 pathway, IL-10 decreased the abundance of the kinases Fyn and Fgr and inhibited the activation of the downstream kinase Syk in mast cells. Together, these findings suggest that an important function of IL-10-producing CD5(+) B cells is inhibiting mast cells and IgE-mediated allergic responses.

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Citations

Jan 24, 2018·Experimental Biology and Medicine·Andrzej GórskiJan Borysowski
May 18, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amina Abdul QayumJohn J Ryan
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Nov 30, 2020·The Journal of Allergy and Clinical Immunology·Anika HabenerGesine Hansen
May 18, 2021·Frontiers in Immunology·Diego CatalánOctavio Aravena

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