Interleukin-10 serum levels and systemic endothelial vasoreactivity in patients with coronary artery disease

Journal of the American College of Cardiology
S FichtlschererA M Zeiher

Abstract

Because the endothelium is a major target for inflammatory cytokines, we investigated whether elevated interleukin (IL)-10 serum levels are associated with improved endothelial vasoreactivity in patients with coronary artery disease (CAD). Chronic inflammation plays a pivotal role in the progression of atherosclerosis. Interleukin-10 is an anti-inflammatory cytokine that exerts important protective effects on atherosclerotic lesion development in experimental animals. Vasoreactivity was assessed in 65 male patients with documented CAD by measuring endothelium-dependent (acetylcholine [ACh] 10 to 50 microg/min) and endothelium-independent (sodium nitroprusside [SNP] 2 to 8 microg/min) forearm blood flow (FBF) responses using venous occlusion plethysmography. Serum levels of IL-10 were significantly correlated with ACh-induced FBF responses (r = 0.31, p < 0.02), but not with SNP responses. Importantly, if IL-10 serum levels were increased in patients with elevated C-reactive protein (CRP) levels, no impairment of ACh-stimulated FBF response was observed. On multivariate analysis, including low-density lipoprotein cholesterol, smoking, hypertension, diabetes, clinical status of the patients, and statin and/or angiotensin-convertin...Continue Reading

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Citations

May 18, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Gyeong-Im YuSeung-Ho Hur
Apr 6, 2013·Cell Biochemistry and Biophysics·Henrique Andrade R FonsecaMaria C Izar
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