PMID: 8972743Dec 1, 1996Paper

Interleukin-10 suppresses the development of collagen type II-induced arthritis and ameliorates sustained arthritis in rats

Scandinavian Journal of Immunology
S PerssonR Holmdahl

Abstract

The collagen-induced arthritis model in DA rats induced with homologous rat type II collagen was chosen to determine the therapeutic capacity and effects on autoimmunity by IL-10. Systemic IL-10 treatment (100 or 10 micrograms/day) with mini-osmotic pumps during the periods of arthritis onset (days 12-20 after immunization) decreased the frequency of arthritis and delayed the onset and reduced the severity of arthritis in the few rats that eventually developed arthritis. Concomitantly, levels of autoantibodies to CII were reduced. To test the activity on established arthritis, IL-10 was administered subcutaneously in the paws. This treatment reduced the swelling but did not block the arthritis process. The effective treatment required 100 micrograms of IL-10 every 12th hour while 50 micrograms of IL-10 had little effect, although a tendency of reduced paw swelling was observed. Surprisingly, therapeutic IL-10 treatment led to higher serum levels of autoantibodies to CII. The highest doses of IL-10 (100 micrograms) did not show any apparent toxic effects when given locally or systematically. Taken together, this study suggests that IL-10 is a candidate for treatment of rheumatoid arthritis.

Citations

Jan 27, 1999·Arthritis and Rheumatism·G J ThorbeckeW J Simmons
Jul 31, 1998·Clinical Immunology and Immunopathology·R R Caspi
Dec 4, 1998·Springer Seminars in Immunopathology·J HermannF M Brennan
Oct 4, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·A D Mancini, J A Di Battista
Nov 10, 2000·Advanced Drug Delivery Reviews·M L Hedley
Mar 11, 1998·Current Opinion in Immunology·A O'GarraK Gijbels
Sep 11, 2002·Cytokine & Growth Factor Reviews·Amy M BeebeRene de Waal Malefyt
Jan 27, 2009·Acta Pharmacologica Sinica·Yan-Li LiuZheng-Hong Qin
Nov 28, 2002·Clinical and Experimental Immunology·I GjertssonA Tarkowski
Mar 17, 1999·The Journal of Experimental Medicine·D J CuaR L Coffman
Dec 21, 2004·Clinical and Experimental Immunology·A-R YoussefC J Elson
May 16, 2002·Infection and Immunity·Manuela PulitiLuciana Tissi
Mar 13, 2001·Annual Review of Immunology·K W MooreA O'Garra
Aug 18, 2004·The Journal of Clinical Investigation·Hiroshi HataShimon Sakaguchi
Dec 9, 2010·The Journal of Veterinary Medical Science·Kazutaka KanaiSeiichi Higuchi
Mar 21, 2012·Critical Reviews in Immunology·Shankar Subramanian Iyer, Gehong Cheng
Jun 3, 2014·Arthritis Research & Therapy·Hélène AsnagliPascale Louis-Plence
Mar 1, 2013·Journal of Leukocyte Biology·Qi-Quan HuangRichard M Pope
Sep 6, 2013·Immunological Investigations·Pedro P C Souza, Ulf H Lerner
Jul 21, 2009·Brain, Behavior, and Immunity·Georg Pongratz, Rainer H Straub
Mar 16, 2007·The Journal of Surgical Research·Fernando López-NeblinaJon Walsh
Jan 27, 2007·The Journal of Surgical Research·Fernando López-Neblina, Luis H Toledo-Pereyra
Nov 1, 2003·Annals of the New York Academy of Sciences·Jean-François Bach
Jan 3, 2013·British Journal of Haematology·Monique E R van MeegerenFloris P J G Lafeber
Aug 25, 2004·Journal of Autoimmunity·Karin LundbergHelena Erlandsson Harris
Apr 21, 2004·Journal of the American Academy of Dermatology·Elliot WeissDaniel Nathan Sauder
Aug 26, 1998·Rheumatic Diseases Clinics of North America·W J WallisE Keystone
Aug 26, 1998·Rheumatic Diseases Clinics of North America·E KeystoneP Grint
Jan 29, 2002·Best Practice & Research. Clinical Rheumatology·H Schulze-Koops, J R Kalden
Mar 20, 2004·The Journal of Veterinary Medical Science·Ken-ichiro HayashidaEtsumori Harada
May 2, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Kou-Zhu ZhuZheng-Hong Qin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.