Abstract
Obesity, characterized by systemic low-grade inflammation, is considered a well-known risk for atrial fibrillation. In fact, IL-10 (interleukin 10), which is a potent anti-inflammatory cytokine, has been reported to decrease in obese and diabetic patients. We tested the hypotheses forwarding that genetic deletion of IL-10 exacerbates high-fat diet (HFD)-induced obesity-caused atrial inflammation, lipidosis, fibrosis, and fibrillation and that IL-10 therapy inhibits this pathology. Eight- to 10-week-old male CL57/B6 (wild-type) mice and IL-10 knockout mice were divided into a 12-week HFD group and a 12-week normal-fat diet (NFD) group, respectively. In addition, the effect of IL-10 administration was also investigated. HFD-induced obesity for 12 weeks significantly depressed serum levels of IL-10 but were found to increase several proinflammatory cytokines in wild-type mice. Adverse atrial remodeling, including atrial inflammation, lipidosis, and fibrosis, was induced in both wild-type and IL-10 knockout mice by HFD. Vulnerability to atrial fibrillation was also significantly enhanced by HFD. With regard to epicardial and pericardial adipose tissue, the total amount of epicardial adipose tissue+pericardial adipose tissue volume ...Continue Reading
References
Aug 13, 2003·Circulation·Nicole H Purcell, Jeffery D Molkentin
Mar 23, 2004·Annual Review of Immunology·Sidney PestkaPaul B Fisher
Nov 25, 2004·JAMA : the Journal of the American Medical Association·Thomas J WangEmelia J Benjamin
Jun 1, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Samir SabaBarry London
Oct 20, 2005·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·M BlüherR Paschke
Aug 29, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Johnson RajasinghRaj Kishore
Dec 15, 2006·Nature·Gökhan S Hotamisligil
Dec 20, 2008·Circulation Research·Prasanna KrishnamurthyRaj Kishore
Mar 7, 2009·Journal of Molecular and Cellular Cardiology·Julie H RennisonMargaret P Chandler
Apr 1, 2008·Circulation. Arrhythmia and Electrophysiology·Stanley NattelDobromir Dobrev
Oct 22, 2009·Biophysical Journal·Mary M MaleckarNatalia A Trayanova
Feb 16, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Jie LiDawood Darbar
Jun 19, 2010·Circulation. Arrhythmia and Electrophysiology·George ThanassoulisEmelia J Benjamin
Nov 3, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Osamu KumeHironobu Yoshimatsu
Jun 3, 2011·The Journal of Clinical Investigation·Carey N Lumeng, Alan R Saltiel
Dec 8, 2011·Journal of Neurochemistry·Koro GotohHironobu Yoshimatsu
Dec 20, 2011·Circulation Research·Takashi AshiharaNatalia A Trayanova
Feb 7, 2012·Circulation·Atsushi AnzaiKeiichi Fukuda
Feb 23, 2012·Circulation. Arrhythmia and Electrophysiology·Yu-Feng HuShih-Ann Chen
Jun 1, 2012·Diabetes·Koro GotohHironobu Yoshimatsu
Jun 19, 2012·Circulation·Suresh Kumar VermaRaj Kishore
Jun 26, 2012·Journal of the American College of Cardiology·Thomas M MungerYong-Mei Cha
Sep 14, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Koki NakanishiMinoru Yoshiyama
Oct 16, 2012·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Hany S AbedPrashanthan Sanders
Dec 12, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Koro GotohHironobu Yoshimatsu
Jan 4, 2013·PloS One·Koro GotohHironobu Yoshimatsu
Feb 15, 2013·Circulation. Arrhythmia and Electrophysiology·Akira FukuiTetsunori Saikawa
Mar 26, 2013·European Heart Journal·Nicolas VenteclefStéphane N Hatem
Aug 2, 2014·Cardiovascular Research·Shotaro SaitoNaohiko Takahashi
Jul 7, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Hidekazu KondoTetsunori Saikawa
Dec 15, 2015·Journal of Molecular and Cellular Cardiology·Kentaro TakahashiTetsushi Furukawa
Citations
Jul 14, 2020·Circulation. Arrhythmia and Electrophysiology·Mark D McCauleyDawood Darbar
Sep 23, 2020·Future Cardiology·William E BodenDeepak L Bhatt
Sep 22, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Arantxa Barandiarán AizpuruaVanessa van Empel
Dec 21, 2018·Frontiers in Physiology·Maria A PabonJames C Lo
Aug 23, 2020·Nutrients·Phil-Kyung ShinSang-Woon Choi
Jul 28, 2020·Circulation Research·Dominik SchüttlerWilliam J Hucker
Oct 6, 2020·Expert Opinion on Drug Discovery·Chun-Ka Wong, Hung-Fat Tse
Oct 20, 2020·Frontiers in Immunology·Jimena RadaNora B Goren
Dec 3, 2020·Journal of the American Heart Association·Miho MiyoshiNaohiko Takahashi
Jan 17, 2021·Journal of Cellular Physiology·Guojian FangQunshan Wang
Jan 28, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Revati S DewalKristin I Stanford
Oct 23, 2020·Antioxidants·Blake H GowenJohn P Morrow
Nov 17, 2020·Frontiers in Pharmacology·Nicholas StaffordDelvac Oceandy
Jan 15, 2021·Proceedings of the National Academy of Sciences of the United States of America·Kelsey H CollinsFarshid Guilak
Dec 10, 2019·Heart, Lung & Circulation·Jiaqi HuangYafei Li
Mar 12, 2021·Circulation Reports·Kunihiko KiuchiKen-Ichi Hirata
Mar 17, 2021·Cardiovascular Research·Martin AguilarSvetlana Reilly
Dec 4, 2020·Journal of Electrocardiology·Utkarsh KohliPriti Jani
May 8, 2021·European Journal of Pediatrics·Lucía Angélica Méndez-GarcíaGalileo Escobedo
May 19, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Marinela Couselo-SeijasSonia Eiras
Jun 12, 2021·Heart Rhythm O2·Hailey J JansenRobert A Rose
Jul 22, 2021·Journal of Cellular and Molecular Medicine·Yuping FuQiangsun Zheng
Aug 1, 2021·Advanced Drug Delivery Reviews·Izabela Tuleta, Nikolaos G Frangogiannis
May 11, 2019·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ana Letícia Vargas BarcelosLuiz Carlos Bodanese
May 6, 2021·Physiological Reviews·Jun RenYingmei Zhang