PMID: 7544991Mar 1, 1995Paper

Interleukin-11 induces phosphatidic acid formation and activates MAP kinase in mouse 3T3-L1 cells

Cellular Signalling
R A Siddiqui, Y C Yang

Abstract

Interleukin-11 (IL-11) stimulated [3H]phosphatidic acid (PA) formation in [3H]arachidonic acid (AA) prelabelled quiescent mouse 3T3-L1 cells. When IL-11 stimulated 3T3-L1 cells were incubated with NaF, a phosphatidic acid phosphohydrolase (PAP) inhibitor, increased PA formation was observed. In the presence of ethanol, phosphatidylethanol accumulated at the expense of PA. These results indicated that the formation of PA upon IL-11 stimulation was a result of phospholipase D (PLD) activation. Endogenous accumulation of PA by NaF treatment or exogenously added PA enhanced tyrosine phosphorylation of two proteins of 44 KDa (p44) and 47 KDa (p47) whereas tyrosine phosphorylation of other proteins was not affected. Among various PA species, dipalmitoyl PA was found to be most effective in enhancing tyrosine phosphorylation of these proteins. p44 and p47 cross reacted with anti-MAP kinase monoclonal antibody (MoAb) in both immunoprecipitation and western blot analysis. Lysates from IL-11-induced or PA-induced cells stimulated phosphorylation of a synthetic peptide substrate for MAP kinase, indicating the activation of MAP kinase in the induced cells. These studies suggest that one of the cellular signalling mechanisms of IL-11 in 3T3...Continue Reading

References

Jul 1, 1992·Journal of Leukocyte Biology·R J SmithJ M Justen
May 1, 1992·Research in Immunology·V F Quesniaux
Oct 23, 1992·Science·T KishimotoT Taga
Jul 1, 1992·European Journal of Immunology·E CanoM Fresno
Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·X P YuS C Manolagas
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·F M UckunJ A Ledbetter
Jan 1, 1991·Cellular Signalling·H E Ives
Oct 1, 1991·Journal of Neurochemistry·J ChattopadhyayH H Schmid
Apr 1, 1991·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E A DennisY A Hannun
Jan 1, 1991·Life Sciences·S D Shukla, S P Halenda
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S B BocckinoJ H Exton
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S R PaulD A Williams
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T SatohY Kaziro
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T SatohY Kaziro
Jul 15, 1990·The Biochemical Journal·M M Billah, J C Anthes
Apr 19, 1990·Nature·M Gopnik
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L B Ray, T W Sturgill
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D K MorrisonT M Roberts
May 29, 1987·Biochemical and Biophysical Research Communications·D W Siegmann
Sep 11, 1986·Nature·W H MoolenaarS W de Laat
Mar 27, 1980·Nature·D M Salmon, T W Honeyman
Nov 19, 1993·Cell·H R Pelham, S Munro
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·H KoideY Kaziro
Nov 1, 1993·Molecular and Cellular Biology·S G MacdonaldF McCormick
Oct 18, 1993·Physical Review Letters·F AbeA G Clark
Aug 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Martin F MillerColin T Pillinger

❮ Previous
Next ❯

Citations

May 24, 1996·Chemistry and Physics of Lipids·D EnglishR A Siddiqui
Jun 7, 2003·Advances in Enzyme Regulation·Raleigh TenneyPhillip H Pekala
Jul 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sean T H LiuThomas Shenk
May 2, 2013·Cell Communication & Adhesion·Lavanya BalakrishnanAditi Chatterjee
May 29, 1997·International Journal of Cancer. Journal International Du Cancer·J A Aguirre GhisoE Bal de Kier Joffé
Feb 22, 2002·The Journal of Biological Chemistry·Jeffrey A Jones, Yusuf A Hannun
Aug 4, 2006·Journal of Neuroscience Research·Sandra E ZulianNorma M Giusto
Jul 21, 1995·Annals of the New York Academy of Sciences·Y C Yang, T Yin
Jan 6, 2005·The Journal of Biological Chemistry·Antonia Avila-FloresIsabel Mérida
Apr 12, 2002·Biochemical and Biophysical Research Communications·Jen Sie Tou
Mar 6, 1997·Biochemical and Biophysical Research Communications·R B MontgomeryW L Stahl
Mar 26, 1998·Biochimica Et Biophysica Acta·T MunnikA Musgrave
Jun 30, 1998·Trends in Biochemical Sciences·M N HodgkinM J Wakelam

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.