Interleukin 11 signaling in 3T3-L1 adipocytes

Journal of Cellular Physiology
Raleigh TenneyPhillip H Pekala

Abstract

Interleukin 11 (IL-11) is an anti-inflammatory cytokine with receptors located on most cell types and tissues throughout the body. Its anti-inflammatory properties are mediated through suppression of cytokine synthesis, in large part by prevention of NF-kappaB activation. As adipose tissue synthesizes and secretes cytokines involved in establishing insulin resistance and due to the ability of IL-11 to suppress cytokine synthesis, we initiated an investigation to determine the signal transduction pathways initiated by IL-11 in adipose tissue. Using the 3T3-L1 adipocyte cell culture model we demonstrate the rapid activation of the p44/42MAP kinase, PI3-kinase, and STATs 1 and 3. Activation of MAP kinase is demonstrated to lead to the downstream activation of p90 RSK (ribosomal S6 kinase) as well as ATF-1 and CREB. PI3-kinase appears to activate the downstream target of p70 S6 kinase resulting in phosphorylation of ribosomal protein S6. STAT phosphorylation appears to be initiated through PI3-kinase and to a lesser degree through p44/42 MAP kinase. These studies demonstrate the activation of three major signaling pathways and support a role for IL-11 in the regulation of both transcription and protein synthesis in fully differenti...Continue Reading

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Citations

Jun 3, 2014·BMC Genomics·Silvia von der HeydeBernhard G Baumgartner
Feb 18, 2015·Biology·Carrie M Elks, Jacqueline M Stephens
May 2, 2013·Cell Communication & Adhesion·Lavanya BalakrishnanAditi Chatterjee
May 13, 2011·Trends in Endocrinology and Metabolism : TEM·Allison J Richard, Jacqueline M Stephens
Sep 1, 2009·Journal of Reproductive Immunology·Pankaj SumanSatish K Gupta
Sep 24, 2013·JAK-STAT·Peng Zhao, Jacqueline M Stephens
Jul 19, 2016·Biochimica Et Biophysica Acta·Kyoungran LeeSuhkneung Pyo
May 25, 2006·The Journal of Biological Chemistry·Raghav RajgopalStephen G Shaughnessy
Sep 8, 2011·Expert Review of Clinical Immunology·Udo R MarkertJustine S Fitzgerald
Dec 4, 2013·The Journal of Clinical Endocrinology and Metabolism·David Sanchez-InfantesJacqueline M Stephens
Sep 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Saeeda Al JaberiErnest A Adeghate

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