Interleukin-12- and interleukin-2-stimulated release of interferon-gamma by uterine CD56++ large granular lymphocytes is amplified by decidual macrophages

Human Reproduction
K MarzuschJ Dietl

Abstract

Numerous studies have suggested that interferon-gamma (IFN-gamma) exhibits an inhibitory effect on conceptus development during pregnancy, and recent investigations have shown that decidual CD56++, CD16- large granular lymphocytes (LGL) contain mRNA for IFN-gamma. We have investigated the influence of exogenous interleukin-12 (IL-12) and interleukin-2 (IL-2) on IFN-gamma secretion by cultivated LGL and macrophages isolated from first trimester human decidua. The effect of decidual macrophages on IFN-gamma secretion by LGL was also assessed using co-incubation experiments. Neither IL-12 nor IL-2 stimulated the secretion of IFN-gamma by decidual macrophages. IL-12 alone, but not IL-2 alone, stimulated the release of IFN-gamma by LGL. However, IL-2 acted synergistically with IL-12 to enhance the release of IFN-gamma by LGL. Unstimulated and IL-12- and IL-2-stimulated LGL incubated with macrophages exhibited a marked increase in secretion of IFN-gamma compared to those in monoculture. This effect was also seen when the LGL and macrophages were separated by a semi-permeable membrane. The results suggest that interactions between decidual LGL and macrophages, possibly mediated by soluble factors, could play a role in regulating IFN-g...Continue Reading

Citations

May 17, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Jacek R Wilczyński
May 10, 2003·Fertility and Sterility·Ulrike von RangoHenning M Beier
Apr 30, 1999·Journal of Reproductive Immunology·D N BurnsR P Nugent
Jul 22, 2006·Journal of Perinatal Medicine·Frank ReisterBerthold Huppertz
Jun 25, 2002·Expert Opinion on Biological Therapy·Jon M Wigginton, Robert H Wiltrout
Feb 14, 2007·American Journal of Reproductive Immunology : AJRI·Sutatip PongcharoenDonruedee Sanguansermsri
Jul 20, 2007·Reproduction in Domestic Animals = Zuchthygiene·T Maj, A Chelmonska-Soyta
Jul 5, 2001·Seminars in Immunology·R Raghupathy
Sep 2, 1999·Human Reproduction·N VassiliadouJ N Bulmer
Oct 16, 2008·American Journal of Reproductive Immunology : AJRI·Oleg PavlovSergei Selkov
Dec 5, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gendie E LashJudith N Bulmer
Jun 13, 2020·Journal of Leukocyte Biology·Soraya Mezouar, Jean-Louis Mege

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