Interleukin-12 as an adjuvant for induction of protective antibody responses.

Cytokine
D W Metzger

Abstract

Interleukin (IL)-12 is a pivotal cytokine that strongly stimulates Th1-associated cellular immunity. It is now recognized that IL-12 also activates humoral immunity to both T-dependent and T-independent antigens. This has let to considerable interest in exploiting IL-12 as a vaccine adjuvant for protection against various bacterial and viral pathogens, particularly in the lung. Studies examining the efficacy of IL-12-mediated effects on protective antibody response in the mouse model are summarized in this review.

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Citations

Jun 23, 2012·American Journal of Respiratory Cell and Molecular Biology·Laura K JohnstonAnne M Manicone
Jan 24, 2012·European Journal of Immunology·Vassili Soumelis
Feb 24, 2015·Cellular Immunology·Melanie R Gubbels Bupp
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Jan 15, 2019·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Yue YinZhiwen Xu
Oct 2, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicole R FordRichard T Robinson
Oct 4, 2018·Molecular Pharmaceutics·Michael A CollierKristy M Ainslie

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