Interleukin-12 from CD103+ Batf3-Dependent Dendritic Cells Required for NK-Cell Suppression of Metastasis

Cancer Immunology Research
Deepak MittalMark J Smyth

Abstract

Several host factors may affect the spread of cancer to distant organs; however, the intrinsic role of dendritic cells (DC) in controlling metastasis is poorly described. Here, we show in several tumor models that although the growth of primary tumors in Batf3-deficient mice, which lack cross-presenting DCs, was not different from primary tumors in wild-type (WT) control mice, Batf3-deficient mice had increased experimental and spontaneous metastasis and poorer survival. The increased metastasis was independent of CD4+ and CD8+ T lymphocytes, but required NK cells and IFNγ. Chimeric mice in which Batf3-dependent DCs uniformly lacked the capacity to produce IL12 had metastatic burdens similar to the Batf3-deficient mice, suggesting that Batf3+ DCs were the only cell type whose IL12 production was critical for controlling metastasis. We found that IL12-YFP reporter mice, whose lungs were injected with B16F10 melanoma, had increased numbers of IL12-expressing CD103+ DCs with enhanced CD86 expression. Bone-marrow-derived DCs from WT, but not Batf3-deficient, mice activated NK cells to produce IFNγ in an IL12-dependent manner and therapeutic injection of recombinant mouse IL12 decreased metastasis in both WT and Batf3-deficient mice...Continue Reading

References

Jun 6, 2000·International Immunology·K TakedaK Okumura
Apr 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·Michele W L TengMark J Smyth
Aug 24, 2011·The Journal of Experimental Medicine·A Nicole DeschClaudia V Jakubzick
Sep 21, 2011·The Journal of Experimental Medicine·Mercedes B FuertesThomas F Gajewski
Jul 14, 2012·Nature Reviews. Immunology·Olivier P JoffreSebastian Amigorena
Sep 21, 2012·Nature·Roxane TussiwandKenneth M Murphy
Oct 30, 2012·Bioinformatics·Alexander DobinThomas R Gingeras
Jun 22, 2013·Nature Reviews. Immunology·Theresa L MurphyKenneth M Murphy
Nov 15, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hemant JaiswalPrafullakumar Tailor
Nov 20, 2013·The Journal of Experimental Medicine·Michaël ChopinStephen L Nutt
Feb 12, 2014·Cancer Immunology, Immunotherapy : CII·Witold LasekMarek Jakobisiak
Mar 20, 2014·European Journal of Immunology·Devika AshokHans Acha-Orbea
Apr 9, 2014·Cancer Immunology, Immunotherapy : CII·Britnie R JamesThomas S Griffith
Dec 4, 2014·Immunobiology·Kevin R MottHomayon Ghiasi
Dec 18, 2014·Cancer Cell·Laurence Zitvogel, Guido Kroemer
Mar 31, 2015·Cell Reports·Ludovic MartinetMark J Smyth
Apr 23, 2015·Proceedings of the National Academy of Sciences of the United States of America·Fernando Souza-Fonseca-GuimaraesMark J Smyth
Dec 30, 2015·The Journal of Experimental Medicine·Bart EvertsEdward J Pearce
May 26, 2016·Cancer Research·Deepak MittalMark J Smyth
Oct 30, 2016·Trends in Immunology·Alycia Gardner, Brian Ruffell
Dec 17, 2016·Cell Research·Leticia CorralesThomas F Gajewski

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Citations

Apr 14, 2019·Cancers·Ben WylieJason Waithman
Jun 22, 2019·Journal of Cellular Physiology·Monireh MohsenzadeganRaheleh Roudi
Feb 7, 2020·Nature Reviews. Immunology·Hannah Garner, Karin E de Visser
Jun 4, 2020·International Journal of Molecular Sciences·Annalisa Del PreteSilvano Sozzani
Jan 11, 2020·Frontiers in Immunology·Nicholas C DeVitoBrent A Hanks
Feb 28, 2019·Frontiers in Immunology·Jean-Charles CancelRaphaël Mattiuz
Jun 9, 2020·Frontiers in Immunology·Alycia GardnerBrian Ruffell
Oct 3, 2020·Biomarker Research·Dragica JorgovanovicYi Zhang
Nov 25, 2020·Journal of Experimental & Clinical Cancer Research : CR·Sepideh NikfarjamReza Jafari
Mar 22, 2019·Cancer Immunology Research·Deepak MittalMark J Smyth
May 31, 2019·Cancer Research·Jennifer L RabeChristopher C Porter
Nov 20, 2020·Cancers·Julien Schaller, Judith Agudo
Feb 19, 2021·The Journal of Experimental Medicine·Genevieve M GerhardMikael J Pittet
Mar 9, 2021·Frontiers in Immunology·Johanna BödderGeorgina Flórez-Grau
Mar 12, 2021·Frontiers in Immunology·Mahdi Abdoli ShadbadBehzad Baradaran
Mar 23, 2019·Trends in Cancer·Erik Wennerberg, Lorenzo Galluzzi
Oct 5, 2020·Seminars in Immunology·Johanna VerneauCheng-Ming Sun
Feb 18, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Melinda L TelliErika J Crosby
Jun 3, 2021·Cancers·Kazuhiko MatsuoTakashi Nakayama
Jun 20, 2020·Immunity·Stephen L Nutt, Michaël Chopin
Nov 18, 2021·Annual Review of Pathology·Laura MaiorinoMikala Egeblad

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