PMID: 8958929Oct 31, 1996Paper

Interleukin-12-induced interferon-gamma inhibits hematopoiesis in vivo in mice

Annals of the New York Academy of Sciences
V F Quesniaux, B Ryffel

Abstract

In vivo administration of interleukin-12 decreases peripheral blood counts and bone marrow hematopoiesis, although in vitro IL-12 was shown to synergize with other cytokines to stimulate the proliferation and differentiation of early hematopoietic progenitors. We investigated whether the in vivo inhibition of hematopoiesis by IL-12 is indirectly mediated by IL-12-induced IFN-gamma. IL-12 was administered to wild-type or IFN-gamma receptor deficient (IFN gamma R-/-) mice. IL-12 treatment resulted in lower peripheral blood counts and a twofold decrease in bone marrow cellularity and hematopoietic progenitors in wild-type mice, but not in IFN gamma R-/- mice. Splenic weight and cellularity were dramatically increased after IL-12 administration in wild-type mice and somewhat less in IFN gamma R-/- mice. The increase was predominantly due to NK cell and macrophage infiltration in wild-type mice, and strong extramedullary hematopoiesis in IFN gamma R-/- mice. Thus, the reduction in total bone marrow cells and hematopoietic progenitor numbers following IL-12 treatment are largely indirect, mediated by IL-12-induced IFN gamma. In the absence of IFN-gamma signaling, IL-12 promotes both bone marrow and splenic hematopoiesis, consistent w...Continue Reading

References

May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·U GublerP C Familletti
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A S SternR Chizzonite
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Feb 1, 1994·Journal of Leukocyte Biology·M J Brunda

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Citations

May 22, 2001·Journal of Hematotherapy & Stem Cell Research·K R MeehanH B Herscowitz
Dec 29, 2000·International Reviews of Immunology·E A Stafford, N R Rose
Oct 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peter W HellingsJan L Ceuppens

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