Interleukin-12 induction of Th1 cytokines is important for viral clearance in chronic hepatitis B

The Journal of Clinical Investigation
S RossolN V Naoumov

Abstract

Interleukin-12, a cytokine with an important role against intracellular pathogens, promotes Th1 cell development, cellmediated cytotoxicity, and interferon-gamma production. We investigated the immunoregulatory role of IL-12 in 72 chronic hepatitis B virus (HBV) carriers, 33 of whom were monitored longitudinally during interferon-alpha treatment. Serum levels of IL-12 heterodimer, IL-12 p40 subunit, IL-4, and Th1 cytokines were determined by specific ELISAs, and hepatitis B core antigen-specific T cell response by a proliferation assay. Chronic HBV carriers had higher serum levels of IL-12 and IL-12 p40 in comparison with controls (P < 0.01), suggesting that IL-12 production is not impaired. The longitudinal analysis revealed a further substantial increase (> 2.5x baseline level) of bioactive IL-12 and Th1 cytokines in patients who cleared HBV and seroconverted to anti- hepatitis B e, unlike the 23 nonresponders with persistent HBV replication (P < 0.01). The IL-12 peak followed the peak of hepatocytolysis by 9.8+/-2.8 wk and occurred either before or simultaneously with hepatitis B e seroconversion. Hepatitis B core antigen-specific T cell proliferation closely correlated with hepatocytolysis and increased significantly in all...Continue Reading

References

Aug 1, 1992·Cellular Immunology·M K GatelyR Chizzonite
May 1, 1989·The Journal of Infectious Diseases·S RossolG Hess
Oct 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G MarinosR Williams
Oct 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F V Chisari
Jul 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H F LöhrG Gerken
Jan 1, 1995·Annual Review of Immunology·F V Chisari, C Ferrari
Jul 18, 1995·Proceedings of the National Academy of Sciences of the United States of America·D R MilichJ E Jones
Jan 28, 1994·Cell·W E Paul, R A Seder
Apr 1, 1994·The Journal of Clinical Investigation·M ZhangP F Barnes
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·L G GuidottiF V Chisari
Jun 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·V J DesmetP J Scheuer
Feb 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G MarinosR Williams
Jun 1, 1993·The Journal of Clinical Investigation·T MaruyamaD R Milich

❮ Previous
Next ❯

Citations

Jul 9, 1999·Reviews in Medical Virology·A R Marques, S E Straus
Apr 16, 2010·Journal of Clinical Immunology·Yufu YeShusen Zheng
Aug 12, 2009·Hepatology International·Hui-Hui TanWan-Cheng Chow
Oct 24, 2001·Antiviral Research·S Zeuzem, V Carreño
Aug 26, 1998·Antiviral Research·J W Cohen StuartR J Whitley
Dec 12, 2001·Journal of Hepatology·D SuriN V Naoumov
Jan 8, 2004·Journal of Hepatology·Carlo FerrariSimona Urbani
Jan 8, 2004·Journal of Hepatology·Pascal LebrayStanislas Pol
Apr 16, 1998·Journal of Hepatology·J VingerhoetsG Leroux-Roels
Jan 23, 1998·Human Immunology·M G ChedidE J Yunis
Mar 6, 1999·Current Opinion in Microbiology·M J EstcourtA J Ramsay
Aug 21, 2003·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Le H SongAdrian J F Luty
Mar 2, 2005·Nature Reviews. Immunology·Barbara Rehermann, Michelina Nascimbeni
Nov 30, 2006·Immunology and Cell Biology·J Judy Chang, Sharon R Lewin
Apr 8, 1999·Clinical and Experimental Immunology·J F SchlaakK H Meyer zum Büschenfelde
Feb 27, 2003·Journal of Gastroenterology and Hepatology·Yun-Fan Liaw
Mar 14, 2007·The Journal of Experimental Medicine·Claire DunnMala K Maini
Nov 5, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·J A CarrA A Nash
Sep 26, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Xiao-Fei KongZhi-Meng Lu
Mar 24, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Tanju B OzkanSibel Aker
Oct 27, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Staffan P E Sylvan, Ulla B Hellstrom
Oct 17, 2012·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Fusun Zeynep AkcamHuseyin Vural
Jan 28, 2004·Journal of Clinical Gastroenterology·Mukadder Ayşe Selimoğlu, Raşit Vural Yağci
Jan 1, 1997·Journal of Viral Hepatitis·N V Naoumov, S Rossol
Jan 1, 2009·Journal of Virology·Julien CrettazGloria Gonzalez-Aseguinolaza
Jan 5, 2007·Journal of Virology·Adam J GehringAntonio Bertoletti
Mar 10, 2001·Microbiology and Molecular Biology Reviews : MMBR·T H Mogensen, S R Paludan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.