Interleukin-12 promotes enhanced resistance to Listeria monocytogenes infection of lead-exposed mice

Toxicology and Applied Pharmacology
H KishikawaD A Lawrence

Abstract

The heavy metal lead (Pb) has been shown to downregulate various parameters of cell-mediated immune (CMI) responses. This inhibition of CMI responses by Pb is exemplified by a higher mortality rate upon infections with sublethal doses of a variety of pathogens. Unlike Pb, which lowers host resistance, interleukin-12 (IL-12) exerts a substantial stimulatory influence on the host response to intracellular bacteria such as Listeria monocytogenes. To explore the influence of IL-12 in mice rendered susceptible to Listerial infection by oral exposure to Pb, we determined bacterial burdens and production of interferon gamma (IFN-gamma). As expected, Pb-exposed mice had increased morbidity due to higher Listerial titers as compared to control mice. However, administration of exogenous IL-12 reversed the Pb-induced inhibition of host defense and boosted the resistance of the non-Pb-treated mice. The enhanced CMI responses observed in both IL-12-treated groups were accompanied with elevations of IFN-gamma in the sera and spleens. Significant reduction in the number of viable Listeria in Pb-exposed mice upon IL-12 administration suggests that the processes downstream of IL-12 production were intact in the Pb-exposed mice and that the inhi...Continue Reading

Citations

Jul 9, 2002·Clinical and Experimental Immunology·H de la FuenteR González-Amaro
Jun 27, 2003·Journal of Toxicology and Environmental Health. Part a·Chad A HudsonDavid A Lawrence
Jul 21, 2006·Journal of Toxicology and Environmental Health. Part a·I DublineauP Gourmelon
Oct 19, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·T L BunnR R Dietert
Nov 8, 2008·Journal of Occupational Medicine and Toxicology·Nasr Ya Hemdan
Sep 30, 1999·Environmental Health Perspectives·U H Rudofsky, D A Lawrence
Mar 4, 2014·Cell Stress & Chaperones·Michael A LynesDavid A Lawrence
Jan 12, 2007·Journal of Periodontal Research·M C P SaraivaB A Burt
Jan 11, 2007·Human & Experimental Toxicology·K P MishraSita Naik
Jun 30, 2004·Human & Experimental Toxicology·Y HeoD A Lawrence
Oct 4, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Qian LiYubin Zhang
Nov 11, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Donghong GaoDavid A Lawrence
Jul 1, 2006·Critical Reviews in Toxicology·Rodney R Dietert, Michael S Piepenbrink
May 28, 2014·Journal of Biochemical and Molecular Toxicology·Jane Kasten-Jolly, David A Lawrence
Mar 1, 2006·Current Protocols in Toxicology·Ling Cao
May 20, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Tingting ZhuYubin Zhang
Jul 13, 2007·International Journal of Immunopathology and Pharmacology·L Di LorenzoL Soleo
Apr 1, 2016·Journal of Veterinary Science·Jae Hee LeeYong Heo
Dec 19, 2017·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Florence Lee, David A Lawrence
Jun 22, 2018·International Journal of Molecular Sciences·Emilia MetrykaIrena Baranowska-Bosiacka
Jun 5, 2003·International Immunopharmacology·Mary L S QueirozSolange Malacrida
Jan 24, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yifan ZhaoYubin Zhang
Jul 5, 2002·Brain, Behavior, and Immunity·Vladimir A Dyatlov, David A Lawrence
Aug 8, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mary L S QueirozChrislaine O Soares

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