Jan 10, 2002

Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair

Nature Cell Biology
Agatha SchwarzThomas Schwarz

Abstract

Induction of apoptosis of keratinocytes by ultraviolet (UV) radiation is a protective phenomenon relevant in limiting the survival of cells with irreparable DNA damage. Changes in UV-induced apoptosis may therefore have significant impact on photocarcinogenesis. We have found that the immunomodulatory cytokine IL-12 suppresses UV-mediated apoptosis of keratinocytes both in vitro and in vivo. IL-12 caused a remarkable reduction in UV-specific DNA lesions which was due to induction of DNA repair. In accordance with this, IL-12 induced the expression of particular components of the nucleotide-excision repair complex. Our results show that cytokines can protect cells from apoptosis induced by DNA-damaging UV radiation by inducing DNA repair, and that nucleotide-excision repair can be manipulated by cytokines.

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Citations

Mentioned in this Paper

Malignant Neoplasm of Skin
IL12A
Apoptosis, Intrinsic Pathway
Edodekin Alfa
DNA Repair
Immunologic Adjuvants
Keratinocyte
Proteins, Recombinant DNA
Base Excision Repair
Nucleotide-excision Repair Complex Location

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis