Interleukin 12B gene polymorphism and apparent resistance to hepatitis C virus infection.

Clinical and Experimental Immunology
Doha HegazyMatthew E Cramp

Abstract

Cellular immunity with interferon gamma production could have a role in protection from hepatitis C virus (HCV). Interleukin (IL)-12 is a key cytokine in promoting such anti-viral T helper 1 (Th1) responses. We hypothesized that a genetic background able to promote cellular responses may be associated with apparent protection from infection and have investigated the distribution of the functional 1188A/C polymorphism of IL-12B in HCV exposed but uninfected cases. The frequency of the high IL-12-producing C allele was determined by restriction enzyme genotyping in 76 exposed-uninfected individuals and 105 healthy controls. Overall, the C allele was found in 27.6% of exposed-uninfected cases compared with 16.7% of healthy controls [chi(2) = 6.3, P = 0.02, odds ratio (OR) = 1.9, 95% confidence interval (CI) = 1.1-3.2]. CC genotype was found in 10.5% of exposed-uninfected cases compared with 0.9% controls (chi(2) = 9.3, P = 0.01, OR = 12, 95% CI = 1.5-100). Individuals at high risk of HCV infection yet who remain uninfected may be resistant in some way to infection. In our cohort of exposed-uninfected cases a genetic background of enhanced IL-12 production was associated with apparent resistance to HCV infection. This lends support...Continue Reading

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Citations

Apr 23, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Samar Samir YoussefSameh Mohamed Seif
Feb 24, 2011·The Journal of Infectious Diseases·Prem H ThurairajahMatthew E Cramp
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Mar 13, 2014·Journal of Medical Virology·Annwyne HouldsworthMatthew E Cramp
Apr 25, 2015·Journal of Medical Virology·Annwyne HouldsworthMatthew E Cramp
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