Interleukin-13 and interleukin-13 receptor in Hodgkin's disease: possible autocrine mechanism and involvement in fibrosis

Histopathology
K OhshimaM Kikuchi

Abstract

Hodgkin's disease (HD) is characterized by the presence of Hodgkin and Reed-Sternberg (H-RS) cells against a hyperplastic background of reactive cells such as lymphocytes, histiocytes, plasma cells, eosinophils, neutrophils, and stromal cells. There is ample evidence to suggest that proliferation and survival of HD-derived cells is due to cytokine signalling. Recently, high expression of interleukin (IL)-13 was described in HD-derived cell lines. Here we investigated the possible involvement of IL-13 in the pathophysiology, especially autocrine pathways of H-RS cells. The expression of IL-13 and IL-13 receptor (IL-13R) was determined by immunostaining and reverse transcriptase-polymerase chain reaction in 39 cases of HD, including 17 cases with nodular sclerosis (NS) type, 19 cases with mixed cellularity (MC), and three cases with lymphocyte predominance (LP) type. Expression of IL-13 was confined to H-RS cells and a few lymphocytes. IL-13R was expressed in H-RS cells, lymphocytes, histiocytes, fibroblasts, and endothelial cells. H-RS cells of MC and NS types frequently expressed both IL-13 and IL-13R. However, the number of IL-13-positive H-RS cells was statistically higher in NS-type than in MC-type, but the number of IL-13R ...Continue Reading

References

Jul 1, 1995·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·R HigginsJ Henrichsen
Jan 1, 1994·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·S M Hsu, P L Hsu
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·M SchenaR W Davis
Nov 15, 1996·The Journal of Biological Chemistry·M J AmanW J Leonard
May 23, 1998·The Journal of Biological Chemistry·H OgataA L Maizel
May 21, 1998·Nature Biotechnology·W DebinskiR K Puri
May 29, 1998·The Journal of Clinical Investigation·C DoucetB Azzarone
May 23, 1998·Annual Review of Immunology·R Küppers, K Rajewsky
Jun 22, 1999·The Journal of Experimental Medicine·U KappT W Mak
Mar 4, 2000·Human Molecular Genetics·A HeinzmannK A Deichmann

❮ Previous
Next ❯

Citations

Dec 15, 2010·Nature Reviews. Nephrology·Yeong-Hau H Lien, Li-Wen Lai
Apr 25, 2009·The Cancer Journal·Franziska C EberleElaine S Jaffe
Mar 5, 2003·Annual Review of Immunology·Thomas A Wynn
Sep 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hua ZhongGalina V Shurin
Jul 12, 2008·American Journal of Respiratory Cell and Molecular Biology·Chun Geun LeeJack A Elias
Mar 26, 2003·American Journal of Respiratory Cell and Molecular Biology·Jack A EliasZhou Zhu
Sep 29, 2011·Environmental Health : a Global Access Science Source·Jimin ZouSandra Leeper-Woodford
Jun 22, 2006·International Journal of Hematology·Marc A WenigerPeter Möller
Jul 13, 2006·Immunogenetics·Brigitte GranelAlain Dessein
May 3, 2008·Leukemia & Lymphoma·José RodríguezMiguel Piris
Jun 30, 2004·Leukemia & Lymphoma·Donatella AldinucciValter Gattei
Aug 3, 2002·Leukemia & Lymphoma·Brian F SkinniderTak W Mak
May 16, 2008·Expert Opinion on Therapeutic Targets·Christian KoeneckeAnke Franzke
Jul 14, 2010·Experimental Hematology·Yanran CaoDjordje Atanackovic
Jun 16, 2009·Clinical Lymphoma & Myeloma·Haresh Mani, Elaine S Jaffe
Jun 5, 2007·La Revue de médecine interne·B GranelA Dessein
Jul 4, 2006·Clinics in Laboratory Medicine·Elliott Kagan
Aug 16, 2008·International Journal of Cancer. Journal International Du Cancer·Frida SchainHans-Erik Claesson
Aug 1, 2015·Biomarkers in Medicine·Carmelo Carlo-Stella, Armando Santoro
Oct 14, 2016·Leukemia & Lymphoma·Philipp LohneisKorinna Jöhrens
Sep 13, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel ReVolker Diehl
Apr 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christian SteidlRandy D Gascoyne
Sep 7, 2007·Pathology, Research and Practice·Canten TatarogluOzlem Aydin
Apr 21, 2016·International Journal of Immunopathology and Pharmacology·Shoko NakayamaMotomu Tsuji
Nov 13, 2018·British Journal of Haematology·Melita CirilloSven Borchmann
May 31, 2002·Blood·Brian F Skinnider, Tak W Mak
Jan 28, 2006·The Journal of Biological Chemistry·Soo Jung ChoChun Geun Lee
Mar 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zhou ZhuJack A Elias
Jan 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bing MaJack A Elias
Dec 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tao ZhengJack A Elias
Apr 3, 2020·Der Pathologe·Anja Mottok
Feb 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qingsheng ChenJack A Elias
Apr 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bing MaJack A Elias

❮ Previous
Next ❯

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