Interleukin 13 and the beta-adrenergic blockade theory of asthma revisited 40 years later

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
R G Townley

Abstract

Beta2-Adrenergic agonists are the most potent agents clinically used in inhibiting and preventing the immediate response to bronchoconstricting agents and in inhibiting mast cell mediator release. This raises the possibility that an abnormality in beta-adrenergic receptor function or circulating catecholamine levels could contribute to airway hyperresponsiveness. To link interleukin 13 (IL-13) to the pathogenesis of asthma. Almost 4 decades ago, Andor Szentivanyi published a beta-adrenergic theory of atopic abnormality in bronchial asthma. He proposed 9 characteristics to define bronchial asthma. Because he published these 9 tenets of the beta-adrenergic blockade theory of asthma in 1968, it is appropriate and important to evaluate their relevance in light of advances in pharmacology, inflammation, and immunology. We describe the effects of the allergic reaction on beta-adrenergic responses and airway responsiveness. Both IL-1beta and tumor necrosis factor a have been detected in increased amounts in bronchial lavage fluids in allergic airway inflammation. Both IL-13 and the proinflammatory cytokines IL-1beta and tumor necrosis factor a have been demonstrated in airway smooth muscle to cause a decreased relaxation response to b...Continue Reading

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Citations

Apr 10, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Robert G TownleyPeter Abel
Nov 29, 2013·Expert Opinion on Biological Therapy·Swati Agrawal, Robert G Townley
Nov 28, 2012·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Robert G Townley, Swati Agrawal
Jun 29, 2016·British Journal of Pharmacology·Cynthia J Koziol-WhiteReynold A Panettieri
Dec 7, 2018·American Journal of Respiratory Cell and Molecular Biology·Christopher D Pascoe, Andrew J Halayko
Sep 4, 2009·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Claudio TerzanoAndrea Lenzi

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