Interleukin 13 (IL-13) alters hypoxia-associated genes and upregulates CD73.

International Forum of Allergy & Rhinology
Syed Muaz KhalilAndrew P Lane

Abstract

Interleukin 13 (IL-13) is a pleiotropic cytokine that has been shown to be important in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP) and other type 2 inflammation-related diseases. Increased IL-13 expression can elicit several pro-inflammatory effects, including eosinophilia, and pathology such as increased mucus secretion. Polypogenesis in chronic rhinosinusitis (CRS) can be caused by hypoxia, which can also lead to hyperpermeability of airway epithelium and epithelium-to-mesenchymal translation through the upregulation of hypoxia-associated genes, such as HIF1. Whether T-helper 2 (Th2) inflammatory cytokines, such as IL-13, can also induce sinonasal epithelial hypoxia-associated genes is currently unknown. Human air-liquid interface (ALI) sinonasal epithelial cell cultures treated with recombinant IL-13 were analyzed by real-time polymerase chain reaction (PCR) and flow cytometry to determine the effect on epithelial cells. Whole tissue from CRSwNP subjects showed increased HIF1A gene expression. Treatment of fully differentiated human ALI cultures with IL-13 resulted in a concurrent increase in HIF1A and ARNT messenger RNA (mRNA) expression. However, the level of EPAS1 expression was significantly re...Continue Reading

References

Jul 1, 1996·Physiological Reviews·H F Bunn, R O Poyton
Sep 25, 2008·Blood·Holger K EltzschigSean P Colgan
Apr 19, 2011·The Journal of Allergy and Clinical Immunology·Julie A PoposkiAtsushi Kato
Dec 20, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Laura E Crotty AlexanderVictor Nizet
Apr 4, 2015·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Richard M RosenfeldMaureen D Corrigan
Apr 4, 2015·Yonsei Medical Journal·Hyun Jin MinChang-Hoon Kim
Feb 3, 2016·JAMA : the Journal of the American Medical Association·Claus BachertE Rand Sutherland
Dec 14, 2016·Annual Review of Pathology·Robert P Schleimer
Mar 25, 2017·Current Allergy and Asthma Reports·Luke Rudmik
Jun 10, 2017·American Journal of Respiratory Cell and Molecular Biology·Hyun-Ah SongChang-Hoon Kim
Jan 26, 2018·BMB Reports·Hyung-Ju Cho, Chang-Hoon Kim
Dec 11, 2019·Nature Reviews. Immunology·Lionel B Ivashkiv
Jan 22, 2020·Annual Review of Immunology·Sean P ColganCormac T Taylor

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