Interleukin-13, in combination with anti-interleukin-12, increases graft prolongation after portal venous immunization with cultured allogeneic bone marrow-derived dendritic cells

Transplantation
R GorczynskiZ Chen

Abstract

Portal venous (pv) transfusion before transplant with large numbers (100 x 10(6)) of irradiated multiple minor histoincompatible spleen cells (B10.Br) augments allogeneic skin graft survival in C3H mice. We have shown in earlier studies that this is correlated with preferential activation for production of type 2 cytokines (interleukin [IL]-4 and IL-10) and decreased production of type 1 cytokines (IL-2 and interferon [IFN] gamma). We have also shown that recombinant (r)IL-12, in association with anti-IL-10 monoclonal antibody, can reverse in vivo the graft prolongation afforded by pv immunization and the altered cytokine production that follows. Adoptive transfer of inhibition of graft rejection is possible at early times after pv immunization, using plastic adherent cells obtained from the liver of treated mice. We show below that within 4 days of pv immunization, dendritic cells (NLDC-145+) isolated from the thymus, mesenteric lymph node (MLN), and.

References

Jun 27, 1992·Lancet·T E StarzlM Trucco
Oct 1, 1995·International Archives of Allergy and Immunology·T Germann, E Rüde
Aug 1, 1995·Current Biology : CB·S L Swain
Nov 1, 1993·The Journal of Experimental Medicine·M B GrahamT J Braciale

❮ Previous
Next ❯

Citations

Mar 27, 2001·Transplantation Proceedings·R GorczynskiJ Gauldie
Mar 8, 2002·Immunology and Cell Biology·Angus W ThomsonLina Lu
Mar 3, 2007·Transplant Immunology·Cassandra DavidsonBruce M Hall
Sep 29, 2007·The Journal of Gene Medicine·Maria SandoviciRobert H Henning
Aug 15, 2001·Seminars in Immunology·A E MorelliA W Thomson
Jan 20, 1998·Biochimica Et Biophysica Acta·Z ChenR M Gorczynski
Sep 27, 2002·American Journal of Reproductive Immunology : AJRI·Reginald M GorczynskiDavid A Clark
Jun 26, 2003·Clinical and Experimental Immunology·P A MorelA W Thomson
Dec 15, 2020·The Journal of Allergy and Clinical Immunology·Juan Manuel Leyva-CastilloRaif S Geha

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.